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Cardio Diabetes Medicine 2017 125

CONCLUSION:
- Epidemiological evidence indicates that plasma TG
levels predict CVD
- The independent relationship between TG and CHD
is more consistently observed in the general popu-
lation. Avoidance of Nicotinic acid ,Smoking,alco-
hol and low fat diet, exercise daily is mandatory.

- Current Hypolipidemic drugs Statin,BAS,fibrates
fish oil.Statin are standard of care for virtutually
all high-risk patients.

- Newer agents-PCSK 9 inhibitor ,MTTP inhibitor,a-
po B inhibitor CETP inhibitor Thyromimitics are on
the pipeline
- Saroglitozar is indicated in RX of hypertriglyceri-
demia.

- Obese patients aerobic exercise, avoidance of
concentrated sugars and medications that raise
serum triglyceride levels and strict glycemic con-
trol in diabetics should be first-line therapy in pa-
tients with mild-to-moderate hyperlipoproteinemia
.Alcohol consumption can have both favorable and
unfavorable effects on CV risk.It is suggested that
in patients mild-to-moderate hyper lipoprotein-
emia, men limit their alcohol consumption to no
more than two drinks per day. Other risk factors
for CV disease such as hypertension and smoking
should also be addressed. In patients with severe
hyperlipoproteinemia (fasting triglyceride levels
above 1,000mg/dL), a very low fat diet and com-
plete avoidance of alcohol is beneficial.options
for pharmacologic therapy directed at reducing
triglycerides include fibrates,nicotinic acid,and fish
oil. 19,52

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An international atherosclerosis society position paper;2013.
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