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Cardio Diabetes Medicine 2017 121

Triglyceride And Cardiovascular

Risk Whats New???

Dr. Aarathy Kannan, MD., Dip in Diab.,

Director, Physician & Diabetologist,
Sundaram Arulrhaj Hospitals,Tuticorin
Dr. Bhubaneshwar, & Dr. Kiran Palsania,
DNB (Gen Med).,

Triglycerides Introduction: tissue. Hypertriglyceridemia is a risk factor for the
• A Triglycerides (TG Triacylglycerol, TAG or Tri- developmentof atherosclerosis. 1
glycerides) is an ester derived from glycerol and • Normal- less than 150mg/dL(1.7mmol/L)
three fatty acids
• Borderline high -150-199mg/dL(1.7-2.2 mmol/L)
• Triglycerides (TG) are an important barometer of
metabolic health. • High-200-499-mg/dL(2.3-5.6mmol/L)
There is increasing evidence that hypertriglyceridemia
• Triglycerides are the main constituents of body fat
in humans and other animals, as well as vegetable is an independent risk factor for coronary artery
fat. disease. A study from international Atherosclerosis
society suggested that Framingham risk score un-
• Main division between saturated and unsaturated derestimates the cardiovascular (CV) risk associated
types. with metabolic syndrome because high triglycerides
• Elevated levels of plasma triglyceride have long are undervalued as a risk factor. 6
been associated with an increased risk of car-
dio-vascular disease.
• TG has an inverse relationship with HDL-C and the
adjustment for HDL attenuates the relationship
between TG and CAD.

HYPERTRIGLYCERIDEMIA:

Definition:
“The current NCEP Adult Treatment panel III(ATPIII)
has defined Hypertriglyceridemia as fasting serum
triglycerides level>150mg/dl[>1.7 mmol/L].”
PREVALENCE OF HYPERTRIGLYCERI-
• Dyslipidemia is defined as total cholesterol low
density lipolrotein - cholesterol (LDL-C), triglycer- DEMIA INDIAN PERSPECTIVE:
ide apolipoprotein (apo)- B, or lipoprotein (a) levels In the recently published Indian council of medical
above the 90 percentile or high density lipo- research- India Diabetes study (ICMR- INDIAB) study
th
protein - cholesterol (HDL-C) or apo-A-I levels in which 16,607 persons (age >20years) from Tam-
below the 10 percentile for the general popu- il Nadu, Maharashtra,Chandigarh, and Jharkhand
th
lation.[National Health and Nutrition Examination were evaluated for lipid and glycemic profile, it was
Survey (NHANES) III triglycerides exist in the core observed that 29.5% population had hypertriglycer-
of chylomicrons and very low density lipoproteins idemia, While 20.2% had isolated hypertriglyceri-
(VLDL). They undergo Hydrolysis by an enzyme demia. 7
lipoprotein lipase be deposited as fat in adipose

Cardio Diabetes Medicine