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538 Initiation & Intensification of Insulin Therapy in T2DM

BIL treatment resulted in significantly lower rates of nocturnal
hypoglycemia compared with insulin glargine in T1DM and T2DM

a Data were adjusted for baseline hypoglycemia characteristics; b Significant difference at endpoint after
adjusting for baseline; Note: a hypoglycemic event was defined as a blood glucose level of ≤70 mg/dL
(3.9 mmol/L) or, where blood glucose was not determined, as signs or symptoms of hypoglycemia 1

1. Rosenstock J et al. Diabetes Care 2013;36:522-8; 2. Bergenstal RM et al. Diabetes Care 2012;35:2140-7

BIL was associated with weight loss in

T1DM and T2DM patients

Weight change from baseline
Mean weightchange in T1DM a Mean weightchange in T2DM
1.0 1.0

0.5 0.5

Δ 1.9 kg, Δ 0.8 kg,
0.0 P<.001 0.0 P<.001
-0.5 -0.5

-1.0 -1.0

-1.5 -1.5
Insulin glargine Insulin glargine
BIL BIL

a Crossover design of T1DM study required analysis by least squares means

Jacober SJ et al. Diabetes Obes Metab 2014;16:351-6

GCDC 2017