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570 Tight Glycemic Control Decreases Cardio Vascular Mortality
(Proponent)

Conclusion
Evidence that hyperglycemia leads to Cardiovascu-
larevents at a rate dependent on both severity and
durationof exposure continues to accumulate. Two
Interventional Studies with 17 and 20 years of fol-
low-up after initiationof treatment early in the natural
history of Diabetessupport the view that treating hy-
perglycemia can reduce Cardiovascular risk [1]. Ag-
gressive treatment ofpatients with long-duration dia-
betes and high Cardiovascularrisk has proved disap-
pointingly ineffective, andthe ACCORD trial showed
increased Cardiovascularmortality, for which neither
Clinical predictors of risknor a probable mechanism
has been well defined [1].

Reference:
1. Endocrinology, Diabetes & Obesity 2011,18:104–109. DOI:10.1097/
MED.0b013e3283446b7e
2. N Engl J Med 2005; 353:2643-2653; December 22, 2005.DOI: 10.1056/
NEJMoa052187
3. Int J Hypertens (2013) 2013:653789. DOI:10.1155/2013/653789.
4. N Engl J Med 2015;372:2197-206. DOI: 10.1056/NEJMoa1414266
5. Diabetes Care, Volume 36, Supplement 2, August 2013.DOI: 10.2337/
dcS13-2018

GCDC 2017