Page 174 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003

A. Secretion and excretion of p-aminohippurate (PAH)
1.00 Excreted PAH
PAH amount/time (mmol/min) 0.75 Secreted PAH

0.50
Saturation
0.25
Filtered PAH Excretion of Organic Substances

0 1 2 3 4 5
PAH concentration in plasma (free PAH) (mmol/L)
–
B. Secretion of organic anions (OA )
Lumen Proximal tubule cell Blood Plate 7.7
Probenecid
OA –
OAT1
3
1 OA –
α-ketoglutarate 2–
PPAH,
OA – hNaDC1 phenol red,
2 hippurate,
ATP 3Na + urate,
4 MRP2 penicillin,
barbiturates,
Amphiphilic diuretics,
OA – conjugates conjugates,
etc.
Excretion
+
C. Secretion of organic cations (OC )
Lumen Proximal tubule cell Blood
OC +
OC +
OCT Epinephrine,
OC + 2 3 choline,
histamine,
H + + serotonin,
OC atropine,
mdr1 quinine,
1 cimetidine,
morphine,
OC + ATP etc.
161
Excretion
Despopoulos, Color Atlas of Physiology © 2003 Thieme
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