Page 292 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003

D. Mode of action of steroid hormones
Steroid
hormone (H)
ECF
Cell
Cytoplasmic
receptor (R)

HSP H-R Cellular Signal Transmission III
complex
Amino acids Trans-
(AA) location
ATP
tRNA DNA
rRNA
AA-tRNA
Translation Transcription
Cell
mRNA nucleus Plate 11.7
Ribosome

Induced Cell response
protein

E. Nitric oxide (NO) as a transmitter substance
Messenger,
e.g., acetylcholine Ca 2+
channel
Cell
Receptor membrane
G o
Vaso- G q DAG Open
dilatation Ca 2+ Calmodulin
PLC-β IP 3
2+
[Ca ]
PIP 2 2+
? Ca
stores Ca -
2+
calmodulin
Protein complex
kinase G
Diffusion
Activated NO synthase
GTP Activated NO Arginine
Cytosolic O 2 ,NADPH
guanylate
cyclase Citrulline
cGMP 279
Cell 2 Cell 1
(e.g., vascular myocyte) ECF (e.g., endothelial cell)
Despopoulos, Color Atlas of Physiology © 2003 Thieme
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