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48   Chapter 2.  Pain

           pain but, as with the previous analgesics, it should be
            delivered an hour before treatment. Additionally, clinicians
           need to be aware of the actions and side-effects of opioids in
           order to achieve good analgesia appropriate for pain man-
           agement. Side-effects may include constipation, nausea/vom-
           iting, sedation and respiratory depression (McNicol et al.
             2003 ).  When used solely for dressing change, practitioners
           need to observe for each of these side-effects at each dose
           administration. Pain can act as an antidote to respiratory
           depression although, if administered during preparation for
           dressing change (hence, a currently pain-free period), it is
           essential to monitor the patients and their safety.
               In addition to the analgesics within the WHO ladder, there
           are co-analgesics that treat non-nociceptive elements of pain.
           Although neuropathic pain and its associated symptoms
           (including allodynia and hyperalgesia) are coincident with
           nociceptive pain, they are unresponsive to the same drugs
           used in the management of nociceptive pain. Differing to
           nociceptive pain, neuropathic pain stems from within the
           nerves themselves, thus medication targeting this area is
           essential.  Antidepressive and anticonvulsant co-analgesics
           such as amitriptyline and gabapentin have proven useful in
           managing such pain. However, clinicians should begin with
           low doses, increasing if need be whilst accounting for poten-
           tial side-effects.
              Other pain management strategies can implement the use
           of nitrous oxide, most commonly the 50:50 strength mixture
           with that of oxygen. Although its mode of action for analgesia
           is unclear, it is often useful when managing painful dressing
           changes. It has very few side-effects and can be self-
           administered via a mouthpiece or facemask. Thus, the patient
           can inhale the substance in accordance with their perceived
           pain. Additionally, nitrous oxide can be used in addition to
           other analgesics with no contraindications. There are limited
           disadvantages to the use of nitrous oxide and numerous
           advantages. Firstly, training in the administration of the
           equipment is relatively simple and quick, the equipment is
           portable, and most forms of the 50:50 mixture are relatively
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