Page 705 - Clinical Application of Mechanical Ventilation
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Case	Studies  671


                                             in 2.0 mL of saline Q 4 hours for wheezing, inline with the ventilator circuit. This
                                             medication was discontinued after her removal from the ventilator.
                                             Weaning


                                             Beginning on the 10th day of mechanical ventilation, the patient began CPAP trials.
                                             She tolerated this procedure well for up to 8 to 10 hours at a time. She was then returned
                                             to SIMV mode with a backup frequency of 6/min, tidal volume of 400 mL (approx.
                                             8 mL/Kg), PEEP of 5 cm H O, F O  of 30%, and pressure support (PS) of 10 cm H O
                                                                    2
                                                                         I
                                                                                                                 2
                                                                           2
                                             to rest for the night. Her frequency remained in the mid to high 20s and her return vol-
                                             ume was consistently between 350 mL and 450 mL. She did not complain of shortness
                                             of breath, difficulty of breathing, or chest discomfort, and appeared to rest comfortably.
                                             By the 12th day of continuous mechanical ventilation, the patient was able to tolerate
                                             CPAP of 5 cm H O and F O  of 30% 24 hours/day. Her ABGs revealed the following:
                                                                   I
                                                           2
                                                                     2
                                                   pH           7.44
                                                   PaCO 2       46 mm Hg
                                                   PaO 2        91 mm Hg
                                                   SaO 2        96%
                                                        -
                                                   HCO          29.9 mEq/L
                                                        3
                                                   Mode         CPAP
                                                   Spont f      28/min
                                                   F O 2        30%
                                                    I
                                                   PEEP         5 cm H O
                                                                       2
                                               At that point, she was removed from the ventilator and placed on a humidified T-
                                             piece (Briggs “T” adaptor) at an F O  of 30%. She was monitored via a continuous-
                                                                          I
                                                                            2
                                             pulse oximeter that revealed SpO  between 92% and 94%. Her frequency remained
                                                                         2
                                             in the low 20s. She was closely observed for signs of respiratory distress or tachypnea
                                             (.30/min). Three days later, ABGs again were obtained while on the T- piece at an
                                             F O  of 30%. These revealed:
                                                 2
                                               I
                                                   pH           7.46
                                                   PaCO 2       45 mm Hg
                                                   PaO 2        87 mm Hg
                                                   SaO 2        96%
                                                         -
                                                   HCO          30.9 mEq/L
                                                        3
                                                   f            24/min
                                               On the 14th day, her tracheostomy was buttoned and she was placed on a nasal
                                             cannula at 2 L/min without complications. She was decannulated two days later.
                                             Complications


                                             The patient showed no serious and lasting complications from this episode of botu-
                                             lism and was discharged from the hospital on room air 21 days following her ad-
                                             mission. She did exhibit some generalized weakness and mild ptosis that continued
                                             to improve after discharge.






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