Page 190 - AACN Essentials of Critical-Care Nursing Pocket Handbook, Second Edition

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Infusion Times/Comments/Drug Interactions Infuse over 60 minutes Infuse over 60 minutes Therapeutic levels: 100-150 mg/L Continuous infusion Infuse over at least 1 hour to avoid “red-man” syndrome Therapeutic levels Peak: 20-40 mg/L Trough

Standard Dilution TMP 16 mg-SMX 80 mg per D 5 W 25 mL TMP 16 mg-SMX 80 mg per D 5 W 25 mL D 5 W 195 mL D 5 W 250 mL 100 U in D 5 W 250 mL

Intravenous Medication Administration Guidelines (continued)

Usual IV Dose Range a 4-5 mg/kg q12h 5 mg/kg q6h 4400 U/kg over 10 minutes, then 4400 U/h over 12 hours 1 g q12h 0.2-0.3 U/min 0.01-0.04 U/min

Drug sulfamethoxazole Common infections GI hemorrhage
Trimethaprim- Urokinase Pulmonary embolism Vancomycin Vasopressin Septic shock
7.1 PCP