Page 194 - AACN Essentials of Critical-Care Nursing Pocket Handbook, Second Edition

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Not associated with histamine release Bile is the main route of elimination No adverse cardiovascular effects No adverse cardiovascular effects renal failure Tachycardia (vagolytic effect)
Comments Metabolized by liver; minimal reliance on renal function, although active metabolite accumulates in real failure Used when succinylcholine is contraindicated or not preferred Predominantly renally eliminated; significant accumulation in M

Onset/Duration Onset: 2 minutes Duration: 30-40 minutes Duration: 15-25 minutes Onset: 4-5 minutes Duration: 55-160 minutes Duration: 35-45 minutes Onset: 2-3 minutes Duration: 60-100 minutes Duration: 25-60 minutes

Neuromuscular Blocking Agents (continued) Dose Intubating dose: 0.1-0.15 mg/kg Maintenance dose: 0.01-0.15 mg/kg Continuous infusion: 1 mcg/kg/min Intubating dose: 0.025-0.8 mg/kg Maintenance dose: 0.005-0.01 mg/kg Continuous infusion: 0.25

Agent Vecuronium Long-Acting Doxacurium Pancuronium
7.2