Page 193 - AACN Essentials of Critical-Care Nursing Pocket Handbook, Second Edition

180

Histamine release with bolus doses 0.6 mg/kg and may precipitate asthma or hypotension Elimination independent of renal hepatic function hydrolysis Duration not prolonged by renal or liver failure Decreased histamine release compared to at

Comments Metabolized in the plasma by Hofmann elimination and ester Used when succinylcholine is contraindicated or not preferred Used when succinylcholine is contraindicated or not preferred Metabolized by liver; duration not significantly prol

Onset/Duration Onset: 2 minutes Duration: 30-40 minutes Duration: 15-25 minutes Onset: 2 minutes Duration: 30-90 minutes Duration: 15-30 minutes Onset: 0.7-1.3 minutes Duration: 22-67 minutes Duration: 12-17 minutes

Neuromuscular Blocking Agents (continued) Dose Intubating dose: 0.5 mg/kg Maintenance dose: 0.08-0.10 mg/kg Continuous infusion: 5-9 mcg/kg/min Intubating dose: 0.15-0.2 mg/kg Maintenance dose: 0.03 mg/kg Continuous infusion: 1-3 mcg/kg/m

Agent Intermediate-Acting Atracurium Cisatricurium Rocuronium
7.2