Page 109 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)
P. 109

+
        D.  Mechanisms of Renal K Loss
         Proximal diuretics  Na +
         Loop diuretics
         Thiazides     Distal             Na +
                       diuretics
                       Aldosterone               K +
                       Flow rate     K +
                                        Cell
                      1
                          Lumen                  Blood                 Processes II
          2
                           CO 2    CO 2        3     Glycosuria
                                                     Type A
                      H +
          Acidosis        HCO 3 –                                      Renal Transport
                           Cl –
                        K +                Glucose excretion/day  Glycosuria
                                              Type B
                                    Cl –                    Normal
                                            0
                                             0      Plasma concentration  Plate 5.4
        E.  Renal Tubular Acidoses
                                       +
                                    –
                             mmol HCO 3 , or H /L GFR
        1             28               2
          25                 3                      28
            –        HCO 3 –   –                             5
         HCO 3   +          HCO 3        21
                H                0.5




                                0.5                           2
            Normal                       Proximal tubular
            acid excretion      pH 5     acidosis            pH 8

        3                              4
                      20                           20
            17               3           19               0.8
                                0.5






         Proximal tubular acidosis  0.5                      0.2
         in reduced                       Distal tubular
         plasma bicarbonate    pH 5       acidosis          pH 7      99

       Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
       All rights reserved. Usage subject to terms and conditions of license.
   104   105   106   107   108   109   110   111   112   113   114