Page 111 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)
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A.  Abnormalities of Urinary Concentration
                                       Mannitol
         Inflammation
                         Loop diuretics
                                         Excretion of:  Diabetes insipidus
                                         glucose,
                      Hypercalcemia      urea,     central  renal
        Mediators                        bicarbonate,
                                         phosphate
                   Hypokalemia
                                                      ADH insensitivity
                   +
                  K  recirculation                 ADH deficiency
                                       Osmolarity                      Concentration
              Blood
              pressure
             Caffeine
                                         4                             Urinary
                                       Water reabsorption
                        ROMK               Osmotic diuresis
                              2                                        Plate 5.5
                                –
                             +
                           +
                         Na -K -2Cl  cotransport
                                                             1
                                                   Water permeability
        Vasodilation
            3

          Perfusion
                                                        Protein deficiency
                                                            5
                                   NaCl and
                                   urea reabsorption        Urea
                Vasa recta


                                                         Collecting duct


                                      Loop of
                                      Henle
                 Osmolarity
                                                Polyuria, nycturia
             NaCl        H 2 O      Urea                              101

       Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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