Page 113 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Glomerular Filtration: Vascular Resistance and Hydraulic Conductivity
Glomerulus
Hydraulic
Normal conductivity
RPF RPF
a P e a P e

π
P eff
Capsular space 8 8
GFR normal Pressure (kPa) 4 ∆P GFR 4
1 0 a ∆π e 2 0 a e

Resistance Resistance Glomerular Function
Vas afferens Vas efferens
RPF RPF
a P e a P e
Plate 5.6
π e
P eff P eff
8 8
GFR GFR
4 4
3 4
0 a e 0 a e
B. Glomerular Diseases
Antigen-antibody Immune complex Masugi’s
complex nephritis nephritis Autoantibodies

e.g.
e.g. Renal vein thrombosis,
Multiple mycloma venous congestion

Protein concentration Hydrostatic
in plasma pressure

Glomerular deposition Glomerulonephritis Abnormalities of
of protein glomerular perfusion
Renal perfusion Death of
GFR Abnormal permselectivity erythropoietin-
forming cells
of the glomerular filter
Renin angiotensin
Hyperhydration
Renal Proteinuria,
hypertension edema Anemia 103
Photos from: Doerr, W. ed. Organpathologie. Stuttgart: Thieme; 1974
Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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