Page 13 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Cell Cycle

Interphase:
6 – 36h Prophase
G2
S
Gap phase 2:
Protein and
RNA synthesis, Cell Adaptation I
S-phase: centriole division Metaphase
DNA replication 1– 2h
8h
Mitosis: M and
Cytokinesis
0,5 – 2h
Gap phase 1:
Growth, Anaphase
differentiation Cell Growth
1– 2h
Gap phase 0:
Liver, kidney, etc.
G1 Plate 1.1
Telophase

M G0

Stimulation of cell division by:
Ultimately no further
e.g. nephrectomy, e.g. subtotal cell division
tubular necrosis hepatectomy
Nerve cells
Erythrocytes
Kidney
Liver
Granulocytes

B. Compensatory Hyperplasia
Metabolic overload,
stress, cytokines, etc.

Expression of Hormones
protooncogenes (norepinephrine,
(c-fos, c-myk) insulin, glucagon)

Growth factors Renewed cell division
(TGFα, HGF, etc.) 3

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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