Page 15 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

C. Regulation of Cell Proliferation, Motility and Differentiation
Growth- Ions Extracellular
promoting matrix
hormones
Cell membrane

Growth
factors Ions Integrins
Messenger and Cell Adaptation II
substances and Cytoskeleton
other signals
Steroid Receptors
hormones

Genome Cell Growth
Cell nucleus
Synthesis of Differentiation Form Migration
growth factors Biosynthesis Adhesion Proliferation Plate 1.2
D. Changes in Cell Population
Stimulated Proliferation Inhibited

Inhibited Apoptosis Stimulated

Larger Cell population Smaller

Stem cell population Differentiation Stem cell population
larger smaller
E. Cell Adaptation
Epithelial Reflux esophagitis
cells (esophageal epithelium)
Pregnancy (uterus) Basal
lamina
Normal Chronic gastritis Smoking
(gastric epithelium) (respiratory
Hypertension Sport epithelium)
(heart) (heart, skeletal
muscles) Pregnancy (uterus)
Plaster cast
(skeletal
muscles)
Metaplasia
Hypertrophy Hyperplasia
Atrophy
5

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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