Page 18 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Intracellular Signal Transmission and Possible Disorders
Inhibitory hormones
Stimulating hormones Receptor
defects
2
Growth factors, 1
insulin, etc. R i
Mutations: R s Activated
Oncogenes β G i protein
γ
β α i
Activated γ GTP
Steroid G s protein
hormones α s Forskolin GDP
GTP Pertussis toxin
Fundamentals Tyrosine kinase GDP Adenylyl Phospho-

cyclase

1 Cholera toxin diesterase Xanthine
derivatives
ATP
10 cAMP 4
AMP

Kinase cascade

Protein kinase A
12
Intracellular
receptor
Cell nucleus

DNA CREB
Receptor defect

mRNA

Induced
protein
Activation or
inactivation of:
8

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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