Page 235 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Causes and Mechanical Consequences of Left Ventricular Failure
Aortic or mitral Myocardial Myocardial Hypertension,
regurgitation infarction ischemia aortic stenosis

Regurgitant Cardiomyopathy
volume Myocardial mass
Pressure load
Hyper-
Volume load Load on remaining Dilated trophic
myocardium Laplace:
P ventr. Wall tension T=
r rises rises P ventr. · radius r
2· wall thickness d
Eccentric Contractility
hypertrophy 1
= cardiac dilation 4 Concentric Heart Failure I
hypertrophy
Systolic or (Ventricular radius r
forward failure normal or reduced)
Ventricular radius r
Hypertrophy
(d rises → T falls) Plate 7.26

C 2 Ventricle
120 C’ less compliant
mmHg
80
SV Diastolic or Decompensation
backward failure (structural dilation)
40 SV’
R ATP deficiency
(myocardial ischemia) SV
0 Restrictive
0 40 120 mL cardiomyopathy
ESV Ventricular filling
ESV’
ESV rises 5
3
120 80
mmHg C SV falls Contractility
80 60
SV
SV’ R’ Stroke volume, SV (mL) 40
40 SV falls
R 20
0 Hyper- trophy Normal Dilated
0 40 80 120 mL
Ventricular filling EDV’ 0 0 50 100 150 200
EDV EDV falls
Enddiastolic volume, ESV (mL) 225

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
All rights reserved. Usage subject to terms and conditions of license.