Page 237 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

B. Heart Failure: Neurohumoral Consequences
Chronic volume Coronary Primary
or pressure load heart disease etc. myocardial damage
Ob-
struction
SV CO Blood Sympathetic tone
pressure
Atrial
Vasoconstriction pressure
(centralization)
Catecholamines
Organ perfusion Symptoms:
Heart failure Skeletal muscle fatigue
Skin Heat sweating
removal
Kidney tachycardia Heart Failure II
Distension ADH

Volume Remodelling Kidney
load RPF falls more Plate 7.27
Renin deeply than GFR
Arrhythmia
Angiotensin II Filtration
fraction
Hyper-
volemia Local: Aldosterone
endothelin Peritubular
TGF, FGF GFR oncotic
NO, PGI 2 pressure
Salt and water
Salt and water retention resorption

Symptoms: Venous pressure
Alveolus
peripheral Systemic
edema Pulmonary
nycturia capillary pressure
Capillary
dyspnea J-receptors Interstitial pulmonary edema
Increasing
•
tachypnea V T heart
Vital capacity failure
Compliance

Work of breathing increased Alveolar pulmonary edema,
hypoxia, hypercapnia 227

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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