Page 289 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Intersexuality
XY chromosomes XX chromosomes
SRY SRY
Testicular development Ovarian development
TDF TDF

MIF Testosterone No MIF and Estrogens
testosterone
1 Normal 2 Normal
Genitals Sexual characteristics Psyche Genitals Sexual characteristics Psyche

XXY chromosomes X0 chromosomes
SRY Intersexuality
Gonadal dysgenesis
Hypotrophic testis
TDF
MIF Testosterone Sexual hormones
3 4 Plate 9.12
Klinefelter’s syndrome Turner’s syndrome
XY chromosomes XX chromosomes + SRY
SRY or XY/X0 mosaic
SRY
Ovaries Hybrid
TDF TDF gonads
No TDF
Estrogens Estrogens
Testosterone
5 6
True
Mutation of SRY gene hermaphroditism
XY chromosomes Tumors, XX chromosomes
exogenous supply Enzyme defects of
Abnormal steroid hormone
synthesis, tumors,
testicular exogenous supply
differentiation
Estrogens
Enzyme defects
Gonadotropins Testosterone
Gonadotropins
7 Testosterone Enzyme Estrogens
defects
Reductase
deficiency 8
Receptor defects
Male pseudohermaphroditism Female pseudohermaphroditism 279

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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