Page 291 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Causes of Hypothyroidism, Hyperthyroidism and Goitre
Hypothalamic
1 Iodine Stress TRH lesion
deficiency
Food
Catecholamines
Dopamine
Iodine excess, Estrogens Somatostatin
rhodanide, etc.
Glucocorticoids
2 Carrier defect TSH Hypo-/Hyperthyroidism, Goitre: Causes
Na +
Pituitary
insufficiency
Autoimmune disease
J –
TSI
Peroxidase
J –
3 Plate 9.13

°
J 2 Peroxidase
deficiency Cell proliferation
Thyroglobulin
OH 4
J J 5 OH Cell damage
by tumor,
OH inflammation etc.
TG J
~DJT TG
Goitre
TG
~MJT Proteolysis
Coupling
6 Defective
OH conversion
J J OH 7
J
T 4
O 8
J J O
J J Genetic defect, T 3
iodine excess,
lithium
TG
~T 4 TG Follicle epithelial cell
Storage ~T 3 of the thyroid Receptor defect
Target organs,
Colloid e.g. heart 281

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
All rights reserved. Usage subject to terms and conditions of license.