Page 41 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. The Erythrocyte Parameters MCH, MCV, and MCHC

Centrifugation
Blood sample MCH (mean Hb mass/RBC)
a
Hb conc.
= (g/RBC)
No. RBC Normal:
b ~30pg
MCV (mean volume of one RBC)
b/a=hematocrit (Hct)
(L RBC /L blood ) Hct
= (L/RBC)
No. RBC Normal: Erythrocytes; Erythropoiesis, Anemia
~90fl
MCHC (mean Hb conc. in RBCs)
Hemoglobin (Hb)
concentration (g/L blood) Hb conc.
= (g/L RBC)
Hct Normal:
Erythrocytes (RBC) ~320g/L
(number/L blood)
MCH / MCV = MCHC
Plate 3.2

Erythrocyte

B. Forms of Anemia
Defect of Erythrocytes
differentiation Virus infection Gene defect Iron deficiency – defects
(membrane,
Autoimmune Folic acid metabolism)
Bone reaction deficiency Defect of – damage
marrow globin synthesis
B 12 deficiency (mechanical,
Renal failure Defect of immunological,
heme synthesis toxic)
– parasites
(malaria etc.)
Blood
Stem cell
Erythrocytic
precursor
Proerythroblast
Erythroblast
Panmyelo-
pathy
Aplastic Erythrocyte
anemia Renal Hemolysis
anemia Megalo-
blastic Microcytic hypo-
anemia chromic anemia
Hemolytic anemia 31
Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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