Page 37 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Obesity
Food intake
and/or
energy consumption
Fat tissue

Hypothalamus
Leptin
‘Eating center’ etc. in plasma Disorders
‘Satiety center’
etc.
MCR-4 receptor Blood-brain
NPY barrier Obesity, Eating
Arcuate
α-MSH nucleus, etc.
Pars
intermedia
? ? ? ? ? Plate 2.4
Receptor defect Release Leptin receptor NPY inhibition Transcytosis
abnormal defect abnormal defect
Obesity
Hypertension Atherosclerosis
Diabetes mellitus II Renal stones
Hyperlipidemia Gallstones
Photo: S. Silbernagl
B. Anorexia Nervosa

Genetic Psychological
predisposition Deliberate changes

Psychological vomiting
factors Abnormal body image Abnormal regulation of
autonomic nervous
Sociocultural Changed food intake (diet) Laxative abuse system and hormones
factors Extreme physical Cortisol
Gonadotropin
activity
Hypothermia
Bradycardia
Loss of hair
Weight loss Photo: W. Nisch etc.
(on average –45%)
Malnutrition
Cachexia 27

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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