Page 43 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Diagnostic Parameters in Anemia
Defect of Virus infection Gene defect Iron deficiency Erythrocytes
differentiation Autoimmune Folic acid deficiency Globin synthesis (defects, damage,
reaction B 12 deficiency defect parasites)
Renal Heme synthesis Chronic
failure defect bleeding
Bone marrow Blood

Hemolysis
Erythrocytic
Stem cell precursor cell Proerythroblast Erythroblast Erythrocyte
Chronic
blood loss Turnover
BFU-E, CFU-E 1 1
Erythrocyte
2
No. of erythroblasts 2
No. of retikulocytes 3 3
Plate 3.3
4 Unconj. bilirubin

5 Erythrocyte life-span
Erythropoietin 6 6

B. Erythropoietin Concentration as Anemia Indicator
e.g.
PO 2 when at high altitude
1 Normal regulation cycle PO 2

Kidney
Erythropoietin

Bone marrow
2 Abnormality of erythrocyte 3 Hemolysis, blood failure 4 Renal failure
or hemoglobin formation
PO 2
PO 2
PO 2
Hemolysis
Loss
Erythropoietin Erythropoietin Erythropoietin

33
Bone marrow

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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