Page 69 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. AIDS
Nucleus
1 Reverse 2
transcriptase CD4-
gp120 gp160 T cell
gp41 CD4
Chemokine Provirus
p24 receptor
HIV-ssRNA
gp120 cDNA
HIV dsDNA
HI-Virion LTR
NFκB Defects
T cell
3 activation
tat Immune
HIV ssRNA
rev

ER Plate 3.16

gp120
Infection
Viremia Viremia Membrane holes
4
CD4-T cells 1000 CD4-T cell death
Concentration IgG (Anti-gp120) 500 CD4-T cells per µL blood CD4-T cell deficiency
IgM
IgG (Anti-p24)
200
p24-Antigen
B cell activation Cellular
abnormal immune reaction
Flulike Asymptomatic
symptoms (2–12 years) ARC AIDS
(4–12 weeks) (2–3 years) (0–1 year)
‘Seroconversion’ Infection with Infection with
extracellular intracellular
pathogens pathogens
‘Naive’
CD8-T cell 5
IFNγ IL-10
IL-2deficiency IL-2 IL-4 Macrophage
Cytotoxic Cytokin concentration activation
T cells TH1 cell deficiency
Time
Resistance to Infection IFNγ deficiency 59
tumor cells Tumor (after Clerici u. Shearer) AIDS
Photo from: Gallo RC. J. Acquired Immune Deficiency Syndromes. 1988; 521-535. ©1988 Raven Press.
With friendly agreement of Lippincott-Raven Publishers, Philadelphia, PA, USA
Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
All rights reserved. Usage subject to terms and conditions of license.