Page 71 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Causes and After-effects of Bleeding Tendency
Thrombocyte deficiency
Vascular disorder or defect
Lack of
plasma factors

Mainly joint bleedings
and blue-black spots Bleeding tendency
(hemorrhagic
diathesis) Mainly petechial hemorrhages Hemostasis I

B. Clotting Tests for Diagnosing Plasmatic Hemorrhagic Diatheses

Common pathway Endogenous system:
Exogenous system: for both systems: factors VIII, IX, XI, XII Plate 3.17
factor VII factors II, V, X as well as HMK
as well as
and prekallikrein
Fibrinogen
Quick value
Partial thrombo-
Thrombin time plastin time (PTT)

C. Interpretation of Clotting Test Results

Probable causes
Quick PTT Thrombo- Bleeding of hemorrhagic diathesis
value cyte count time (applied to moderate to severe disorders)
normal normal normal normal Vascular cause, factor XIII deficiency
normal normal normal Factor VII deficiency
normal normal normal Heparin administration, deficiency of factor VIII, IX, XI,
XII, HMK or prekallikrein
normal normal Thrombocytopenia
Administration of coumarin derivatives,
normal normal vitamin K deficiency, factors I, II, V, X deficiency
normal normal v. Willebrand’s disease
Liver damage, consumption coagulopathy, sepsis
(after E. Lechler)
reduced prolonged 61
Photo : Siegenthaler W. Differentialdiagnose innerer Krankheiten.
17th ed. Stuttgart: Thieme; 1993.
Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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