Page 89 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Emphysema
Chronic obstructive α 1 -proteinase inhibitor Elastase excess
lung disease
Breakdown of connective
tissue in the lung
Aging etc.
Centrilobular Panlobular
Emphysema
Bronchioles
Respiratory
bronchioles
Alveolar Emphysema
ducts
Flaccid lung
Alveoli
Pulmonary

Bronchial Loss of Capillary Loss of
obstruction diffusion area destruction retractability (recoil)
T RL
Abnormal Abnormal diffusion Work: Plate 4.7
distribution Cardiac
output (CO) · T
Increased V max =
dead space Compensation RL
Hypoxemia through inspiration
T RL
Pulmonary vasoconstriction Deepened
breathing
·
Pulmonary hypertension V max = T
RL
‘Blue Right heart failure
bloater’ ‘cor pulmonale’ ‘Pink puffer’ ‘Barrel chest’

B. Development of Barrel Chest in Emphysema

Tidal
volume
Vital capacity

Residual Functional residual capacity Total capacity
volume

Normal ‘Barrel chest’
inspiratory position in emphysema 79

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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