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126  P R I N C I P L E S   A N D   P R A C T I C E   O F   C R I T I C A L   C A R E



            Case study, Continued
            Initial treatment included: 15L oxygen via non-rebreather system,   Day 2
            fluid  resuscitation  of  1.5L  with  the  blood  pressure  improving  to   Kevin remained on Pressure control ventilation: FiO 2  0.5–1.0, PEEP
            111/42, and broad specrum antibiotics.            @ 15, Inspiratory Pressure @ 16 with Nitric Oxide 5–10ppm. Hae-
            An  urgent  portable  chest  X-ray  showed  right  middle  and  lower   modynamics  were  supported  with  noradrenaline,  adrenalin  and
            lobe consolidation and air bronchograms.          bicarbonate infusions. Kevin was sedated and administered bron-
                                                              chodilators.  Antibiotic  treatment  continued  with  blood  cultures
            While there was improvement to SpO 2  readings with the supple-  positive for streptococci. Renal function was supported with Hae-
            mental oxygen therapy, Kevin’s work of breathing remained high   mofiltration.  Re-positioning  Kevin  was  limited  to  small  lateral
            and following consultation with the intensive care team, arrange-  movement because of his continued haemodynamic and respira-
            ments were made to transfer Kevin via helicopter to the intensive   tory  instability.  Passive  movements  of  all  limbs  were  instigated
            care unit in the city.                            with physiotherapists assisting with limb and joint movements.
            On arrival in ICU                                 Kevin’s  problems  were  severe  community  acquired  pneumonia,
            Because of the high suspicion of influenza and the serious respira-  shock, acute renal failure and coagulopathy.
            tory failure necessitating respiratory support and potential for intu-
            bation or bronchoscopy, Kevin was allocated to a single room and   Days 3–6
            ‘contact and droplet’ transmission-based precautions were imple-  Volume control ventilation with tidal volumes of 6 mL/L/kg along
            mented immediately.                               with nitric oxide therapy were used to support respiratory func-
                                                              tion. PiCCO monitoring was implemented to assist management of
            During transport from the country to the ICU, the retrieval team   haemodynamic status and continuous veno-venous haemodiafil-
            had  stabilised  Kevin  on  supplemental  oxygen  therapy  but  just   tration (CVVHDF) was used for renal support. Strep pyogenes and
            prior  to  arrival in the  ICU  he was increasingly  disorientated  and   Influenza A H1N1 were confirmed and antibiotic therapy contin-
            dyspnoeic and BiPAP therapy was commenced with FiO 2  1.0. The   ued. Enteral nutrition was commenced and established over a 4
            retrieval  team  has  inserted  a  central  venous  catheter  and  com-  day  period.  A  faecal  containment  device  was  used  to  manage
            menced a low dose adrenaline infusion to support his blood pres-  incontinence and prevent any sacral excoriation.
            sure as they did not want to load him with fluids. During transport
            Kevin was able to tolerate being semi-recumbent but unable to be   Days 7–13
            positioned sitting upright while on the barouche due to his large   Inotropes  were  gradually  weaned  and  respiratory  function
            abdomen causing discomfort to his breathing.      improved  and  nitric  oxide  ceased.  During  this  time  Kevin  was
                                                              progressively  re-positioning  more  often  and  with  increasing
            Kevin was unable to be stabilised on BiPAP and was intubated and   lateral turns to aid both his respiratory function and also provide
            ventilated using FiO 2 1.0 with PEEP @ 8 on pressure control ventila-  pressure relief. Sedation was reduced over this time and ceased
            tion  (PCV)  mode.  Tracheal  aspirate  was  obtained  and  sent  for   and  Kevin  was  changed  to  pressure  support  ventilation  (PSV).
            microbiological examination including a rapid review for influenza.   Kevin responded with his eyes opening to stimuli but he had hypo-
            A  urinary  catheter  with  temperature  monitoring  sensor  was   tonic and areflexic upper and lower limbs. A short-term clonidine
            inserted. Kevin was oliguric and his urinary temperature was 39°C.   infusion  was  required  for  control  of  a  period  of  severe
            Kevin’s haemodynamic instability and de-saturation due to lung   hypertension.
            compression  prevented  him  from  being  positioned  laterally  but
            head-of-bed elevation was maintained at greater than 20 degrees.   Days 14–20
            From initial contact with the local hospital knowledge of Kevin’s   Nerve conduction studies confirmed that Kevin had a critical illness
            weight had prompted the ICU team to ensure that the bed Kevin   polyneuropathy.  A  progressively  increasing  respiratory  rate  and
            used  had  a  weight-suitable  pressure  relief  mattress  already  in   decreasing PaO 2  due to low tidal volumes prompted a short return
            place.  Venous  thromboembolism  prophylaxis  was  commenced   to pressure-controlled ventilation to re-inflate the lower lobes. A
            with a combination of heparin and sequential compression device.   tracheostomy was performed to provide long term airway support.
            Thigh leggings were chosen along with the sequential compres-  Kevin  improved  again  over  the  next  24  hours  and  was  weaned
            sion  device  in  preference  to  compression  stockings  because  of   again to 30% oxygen on pressure support ventilation.
            Kevin’s size and potential peripheral oedema.
                                                              Days 21–25
            After 12 hours following intubation, nitric oxide was added to the   Kevin’s limb strength improved with power rated at 4/5 globally.
            ventilation  system  to  improve  arterial  blood  gases  (ABGs)  along   Kevin was now able to be supported to sit on the side of the bed
            with  intermittent  muscle  relaxants  which  were  also  required  to   twice each day. T-piece oxygenation was now well tolerated during
            optimise ventilatory support. Additional attention to Kevin’s eye   the day with pressure support ventilation at night. A renal perfu-
            care was given with the use of muscle relaxants and the subse-  sion scan showed poor perfusion with very delayed function and
            quent loss of blink reflex. Hypotension was treated with a further   no  radioactive  excretion.  A  permacath  was  inserted  to  aid  with
            2 litres of intravenous fluids plus 2 units of red blood cells for a low   potential long-term dialysis.
            haemoglobin. Antibiotic therapy continued.
                                                              Days 26–34
            Kevin’s problems included community acquired pneumonia, sepsis   Respiratory support was continued with a variation between pres-
            and acute renal failure.                          sure  support  ventilation  and  T-piece  oxygenation.  Intermittent
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