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Neurological Alterations and Management  473



               Case study
               Sam, a 21-year-old male driver was involved in a high-speed motor   haemothorax, fractures 1st to 10th right ribs, transverse spinal T7
               vehicle accident on the outskirts of a regional town; car versus a   to T10 and L 1 to L5. The CT of the abdomen showed extensive
               telegraph  pole  at  high  speed  with  two  other  people.  Sam  was   subcutaneous gas extending from the lumbar spine into the peri-
               partially ejected but his head was trapped between the steering   toneal cavity and was in communication with the caecum.
               wheel  and  the  seat.  When  the  ambulance  officers  arrived  on    Following the X-rays, Sam returned to the OT for further explora-
               the  scene, he was  unconscious  (GCS  3)  and pupils  non-reactive.     tion of abdomen and insertion of ICP monitor. Intraoperatively he
               His  breathing  was  obstructed  with  stridorous  respirations  and   remained  hypotensive  despite  intravenous  titration  of  triple
               decreased air entry to the right lung. He was bleeding profusely   therapy inotropes. On return to the ICU, Sam’s ICP was 10. Blood
               from his nose, mouth and open head lacerations. Ambulance staff   pressure remained labile and cerebral perfusion pressure fluctu-
               cleared  his  airway,  fitted  a  C  spine  collar,  administered  oxygen,   ated between 50 and 70. Sam had to be paralysed as he began
               obtained IV access and transported him to hospital within thirty   shivering from attempts to reduce his temperature (39°C) with a
               minutes. Of the two other occupants one was deceased and the   related rise in his ICP to 25 mmHg. His GCS remained at 3 through-
               other had life-threatening injuries that required transportation to   out, sedated with midazolam and fentanyl. 3% saline boluses were
               hospital.
                                                                  initiated to reduce elevated ICP (25) in an attempt to improve his
               On arrival in the Emergency Department (ED) at 0130h, Sam had a   CCP to >60 mmHg.
               GCS  5  (Eyes  opening  1, Verbal  response  1,  Movement  3),  pupils   Days 2 and 3
               were  midpoint  and  sluggish  (size  2).  Rapid  sequence  induction   For the next two days, Sam remained paralysed and sedated. His
               intubation  was  performed  due  to  an  obstructing  airway.  Initial   GCS remained at 3. His ICP ranged from 8 to 15. Interventions were
               observations were: HR 130, BP 130/60, SpO 2  100% on FiO 2  1.0. Prior-  related to a rise in ICP up to 30, but returned to baseline shortly
               ity  was  given  to  the  other  injured  occupant  to  go  to  X-ray  for   afterwards. CCP was maintained at 60–65 with noradrenaline and
               trauma series of N-rays first. The X-ray department at this regional   vasopressin. Pupils reacted sequentially to light size 2.
               hospital had one CT scanner and was staffed with only one techni-
               cian after midnight.                               Sam continued to be tachycardic (130) and remained febrile (38.8)
                                                                  despite  aggressive  attempts  to  lower  his  temperature.  A  DIC
               Within  the  second  hour  of  being  in  ED,  Sam  became  haemody-  picture  was  developing  evident  by  the  drop  in  platelets  and
               namically unstable. His HR increased to 150, SBP dropped to 70 and   increase in INR. The paralysing medication prescription was ceased.
               Hb dropped from 150 to 108 g/L. The second FAST scan revealed   GCS remained at 3 (E1, V1(ETT), M1) with IV infusions of fentanyl
               fluid in the left internal flank region adjacent to penetration injury   and  midazolam.  Noradrenaline  and  vasopressin  infusion  were
               to L groin. The decision was made to forgo further trauma series    weaned off over the day.
               of X-rays and transport Sam to the operating theatre for an emer-  Day 4
               gency laparotomy. In OT Sam remained unstable. He was tachy-  Sam’s sedation was ceased to facilitate a neurological assessment.
               cardic with HR 130–150, blood pressure maintained with packed   He achieved a GCS of 5 (E1, V1 (ETT), M3). ICP fluctuated between
               red cell transfusion (10 units), fresh frozen plasma (4 units), plate-  9 and17 with CPP maintained at 60–65. A repeat CT showed new
               lets  (1  unit)  (only  one  unit  of  platelets  available  at  this  regional   small parafalcine subdural, left temporal bone fracture, diffuse con-
               hospital; if more was required it needed to be ordered from inter-  tusions in frontal and occipital regions with extensive oedema. He
               state) and colloids. Oxygenation was maintained but EtCO 2  ranged   was re-sedated with fentanyl and propofol infusions.
               from 50–70.
                                                                  Weeks 1–3
               The operating theatre had one team on at this hour of night, and   Daily neurological assessment occurred with gradual reductions in
               due  to  the  complexity  and  instability  of  patient,  the  EtCO 2   was   sedation requirements. Sam began to open his eyes spontaneously
               not able to be managed aggressively with resources available at   but  was  increasingly  agitated  and  restless.  ICP  monitoring  was
               the time. Surgical repairs were made to perforations in caecum,   removed on day 6 and seizure activity was suspected. Phenytoin
               colon and liver and the groin wound was explored, cleaned and   was prescribed and commenced.
               sutured.
                                                                  Sam  had  a  tracheotomy  performed  to  facilitate  weaning  from
               Vital signs on arrival in ICU                      mechanical ventilation. The weaning process was delayed due to
               Temperature 37.8°C, HR = 155, BP = 90/40 MAP 61, EtCo 2  50, Pupils   a  further  eight  visits  to  OT  for  removal  of  necrotic  tissue  and
               size 2 and reacting. Sam remained ventilated (SIMV VC 18 × 450, PS   abdominal  washouts  related  to  intra-abdominal  and  right  flank
               10, PEEP 10, FiO 2  0.95) and sedated with an IV infusion of fentanyl   injuries.
               and  midazolam.  Spinal  precautions  were  maintained  with  hard
               collar and neck in neutral position. Noradrenaline, adrenaline and   Eventually Sam was discharged to a surgical ward with impending
               vasopressin were commenced to support his MAP which remained   transfer  to  a  rehabilitation  facility  interstate.  GCS  was  at  13  (E4,
               labile (range 49 to 60 mmHg).                      V1 4, M 5) at the time of discharge to ward.
               Five  hours  after  admission  to  ICU,  Sam  was  taken  to  the  CT    On discharge (16 weeks later)
               department  to  have  the  full  trauma  series  of  X-rays  completed.    Sam was decannulated and his GCS was 14 (E4, V1 5, M 5). He was
               The  brain  CT  showed  diffuse  oedema  and  foci  of  haemorrhage   transferred  to  a  rehabilitation  facility  interstate  to  continue  his
               related to the splenium or posterior portion of the corpus callosum     rehabilitation. Rehabilitation service at the regional hospital was
               and  right  frontoparietal  cortex.  Sam’s  other  injuries  included:  R   not equipped to deliver the amount of rehabilitation services that
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