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ONLINE RESOURCES 13. Singer M, De Santis V, Vitale D, Jeffcoate W. Multiorgan failure is an adaptive,
endocrine-mediated, metabolic response to overwhelming systemic inflam-
The Institute for Healthcare Improvement (IHI) is a non-profit organisation for mation. Lancet 2004; 364(9433): 545–8.
advancing the quality and value of health care. The sepsis link includes infor- 14. Jastrow K, Gonzalez E, McGuire M, Suliburk J, Kozar R et al. Early cytoline
mation about improving care and severe sepsis bundles, http://www.ihi.org/ production risk stratifies trauma patients for multiple organ failure. J Am Coll
ihi/topics/criticalcare/sepsis Surgeons 2009; 3(209): 320–31.
The Surviving Sepsis guidelines webpage provides access to full text documents 15. Bone RC. Immunologic dissonance: a continuing evolution in our under-
here and updates, http://www.survivingsepsis.org standing of the systemic inflammatory response syndrome (SIRS) and the
The US National Institutes of Health clinical trials registry. Search the site for multiple organ dysfunction syndrome (MODS). Annals Internl Med 1996;
currents trials in MODS, http://www.clinicaltrials.gov 125(8): 680–87.
16. Bridges EJ, Dukes S. Cardiovascular aspects of septic shock: pathophysiology,
monitoring, and treatment. Crit Care Nurs 2005; 25(2): 14–40.
FURTHER READING 17. Padgett DA, Glaser R. How stress influences the immune response. Trends
Immunol 2003; 24(8): 444–8.
Bagshaw S.M, Lapinsky S, Dial S, Arabi Y, Dodek P et al. Acute kidney injury in 18. Hubbard WJ, Bland KI, Chaudry IH. The role of the mitochondrion in
septic shock: clinical outcomes and impact of duration of hypotension prior trauma and shock. Shock 2004; 22(5): 395–402.
to initiation of antimicrobial therapy. Intensive Care Med 2009; 35(5): 19. Adrie C, Pinsky MR. The inflammatory balance in human sepsis. Intens Care
871–81. Med 2000; 26(4): 364–75.
Kumar A, Roberts D, Wood K, Light B, Parrillo J et al. Duration of hypotension 20. Magder S, Cernacek P. Role of endothelins in septic, cardiogenic, and hemor-
before initiation of effective antimicrobial therapy is the critical determinant rhagic shock. Can J Physiol Pharmacol 2003; 81(6): 635–43.
of survival in human septic shock. Crit Care Med 2006; 34(6): 1589–96. 21. Zingarelli B, Sheehan M, Wong HR. Nuclear factor-kappaB as a therapeutic
Kumar A, Ellis P, Arabi Y, Roberts D, Light B et al. Initiation of inappropriate target in critical care medicine. Crit Care Med 2003; 31(Supp): S105–11.
antimicrobial therapy results in a fivefold reduction of survival in human 22. Brealey D, Brand M, Hargreaves I, Heales S, Land J et al. Association between
septic shock. Chest 2009; 136(5): 1237–48. mitochondrial dysfunction and severity and outcome of septic shock. Lancet
Le Manach M, Ibanez Esteves C, Bertrand M, Goarin JP, Riou B, Landals P. Impact 2002; 360(9328): 219–23.
of preoperative statin therapy on adverse postoperative outcomes in patients 23. Sherwood E, Toliver-Kinsky T. Mechanisms of the inflammatory response.
undergoing vascular surgery. Anaesthesiol 2011; 114(1): 98–104. Best Prac Res Clin Anaesthesiol 2004; 18(3): 385–405.
Madách K, Aladzsity I, Szilágyi Á, Fust G, Gál J et al. 4G/5G polymorphism of 24. Weigand M, Horner C. The systemic inflammatory response syndrome. Best
PAI-1 gene is associated with multiple organ dysfunction and septic shock in Prac Res Clin Anaesthesiol 2004; 18(3): 455–75.
pneumonia induced severe sepsis: prospective, observational, genetic study. 25. Arias J-I, Aller M-A, Arias J. Surgical inflammation: a pathophysiological
Critical Care 2010; 14(2): R79. rainbow. J Translation Med. 2009; 7(19). Available from: http://
Moore FA, Moore EE. The evolving rationale for early enteral nutrition based on www.translational-medicine.com/content/pdf/1479-5876-7-19.pdf.
paradigms of multiple organ failure: a personal journey. Nutr Clin Practice 26. Kirschfink M. Controlling the complement system in inflammation. Immu-
2009; 24(3): 297–304. nopharmacol 1997; 38(1–2): 51–62.
Perel A. Bench-to-bedside review: The initial hemodynamic resuscitation of the 27. Dishart MK, Schlichtig R, Tonnessen TI, Rozenfeld RA, Simplaceanu E et al.
septic patient according to Surviving Sepsis Campaign guidelines – does one Mitochondrial redox state as a potential detector of liver dysoxia in vivo. J
size fit all? Crit Care 2008; 12(5): 223. Applied Physiol 1998; 84(3): 791–7.
28. Fishel RS, Are C, Barbul A. Vessel injury and capillary leak. Crit Care Med
REFERENCES 2003; 31(8): S502–11.
29. Calandra T, Cohen J. The international sepsis forum consensus conference
1. Jackson W, Gallagher C, Myhand R, Waselenko J. Medical management of on definitions of infection in the intensive care unit. Crit Care Med 2005;
patients with multiple organ dysfunction arising from acute radiation syn- 33(7): 1538–48.
drome. Brit J Radiol 2005; (27): 161–8. 30. Bernard GR, Macias WL, Joyce DE, Williams MD, Bailey J, Vincent JL. Safety
2. Bone R, Balk R, Cerra F, Dellinger R, Fein A et al. Definitions for sepsis and assessment of drotrecogin alfa (activated) in the treatment of adult patients
organ failure and guidelines for the use of innovative therapies in sepsis. The with severe sepsis. Crit Care 2003; 7(2): 155–63.
ACCP/SCCM Consensus Conference Committee. American College of Chest 31. Micek ST, Shah RA, Kollef MH. Management of severe sepsis: integration of
Physicians/Society of Critical Care Medicine. Chest 1992;101(6): 1644–55. multiple pharmacologic interventions. Pharmacotherapy 2003; 23(11):
3. Al-Khafaji A, Sharma S. Multisystem organ failure of sepsis. eMedicine Critical 1486–96.
Care. 2010. Available from: http://emedicine.medscape.com/article/ 32. Annane D, Bellissant E, Cavaillon JM. Septic shock. Lancet 2005; 365(9453):
169640-overview. 63–78.
4. Marshall JC. The multiple organ dysfunction syndrome. Surgical treatment: 33. Amaral A, Opal SM, Vincent JL. Coagulation in sepsis. Intens Care Med 2004;
evidence based and problem oriented. 2001: Available from: http:// 30(6): 1032–40.
www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=surg&part=A5364. 34. Rice TW, Bernard GR. Drotrecogin alfa (activated) for the treatment of severe
5. Deitch E. Multiple organ failure: pathophysiology and potential future sepsis and septic shock. Am J Med Sci 2004; 328(4): 205–14.
therapy. Ann Surg 1992; 216(2): 117–34. 35. Sharma S, Eschun G. Multisystem organ failure of sepsis. eMedicine Critical
6. Barie P, Hydo L, Shou J, Eachempati S. Decreasing magnitude of multiple Care. 2004. Available from: http://www.emedicine.com/med/topic3372.htm.
organ dysfunction syndrome despite increasingly severe critical surgical 36. Doshi SN, Marmur JD. Evolving role of tissue factor and its pathway inhibi-
illness: a 17-year longitudinal study. Trauma 2008; 65(6): 1227–35. tor. Crit Care Med 2002; 30(Suppl): S241–50.
7. Papathanassoglou E, Bozas E, Giannakopoloulou M. Multiple organ dys- 37. Liaw P. Endogenous protein C activation in patients with severe sepsis. Crit
function syndrome pathogenesis and care: a complex systems’ theory per- Care Med 2004; 32(5): S214–18.
spective. British Association of Critical Care Nurses.Nurs Critical Care 2008; 38. Tortora G, Grabowski S. Principles of anatomy and physiology, 10th edn. New
13(5): 249–59. York: Wiley & Sons; 2003.
8. Pinsky M, Al Faresi F, Brenner B, Dire D, Filbin M, Flowers F, Gaeta T et al. 39. Hameed SM, Aird WC, Cohn SM. Oxygen delivery. Crit Care Med 2003;
Septic shock. eMedicine Critical Care. 2011. Available from: http:// 31(12Suppl): S658–67.
emedicine.medscape.com/article/168402-overview. 40. Trager T, DeBacker D, Radermacher P. Metabolic alterations in sepsis and
9. Fink M. Cytopathic hypoxia in sepsis. Acta Anaesthesiol Scand 1997;110(Suppl.): vasoactive drug-related metabolic effects. Curr Opin Crit Care 2003; 9(4):
87–95. 271–8.
10. Henke K, Eigisti J. Self-annihilation: a cells story of suicide. Dimens Crit Care 41. Sundararajan V, Macisaac C, Presneill J, Cade J, Visvanathan K. Epidemiology
Nurs 2005; 24(3): 117–19. of sepsis in Victoria, Australia. Crit Care Med 2005; 33(1): 71–80.
11. Saukkonen K, Lakkisto P, Varpula M, Varpula T, Voipio-Pulkki L-M et al. 42. Ferreira FL, Bota DP, Bross A, Melot C, Vincent JL. Serial evaluation of the
Association of cell-free plasma DNA with hospital mortality and organ SOFA score to predict outcome in critically ill patients. JAMA 2001; 286(14):
dysfunction in intensive care unit patients. Intens Care Med 2007; 33(9): 1754–8.
1624–7. 43. Micek ST, Isakow W, Shannon W, Kollef MH. Predictors of hospital mortality
12. Mizock BA. Metabolic derangements in sepsis and septic shock. Crit Care for patients with severe sepsis treated with Drotrecogin alfa (activated).
Clinics 2000; 16(2): 319–36. Pharmacotherapy 2005; 25(1): 26–34.