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1566   Part IX  Cell-Based Therapies

                                                              REFERENCES
         Cryobiology and Fitness of Thawed MSC Cellular Pharmaceuticals
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          tions, express major histocompatibility complex class I molecules as   12.  Dominici M, Le Blanc K, Mueller I, et al: Minimal criteria for defining
          well as surface CD105, CD90, CD73, and CD44; lack expression of
          hematopoietic markers CD45, CD34, CD11b, and CD19; and retain the   multipotent  mesenchymal  stromal  cells. The  International  Society  for
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          vitro (Table 99.1). Although useful in confirming identity, these markers   PMID 16923606. 150.
          have  virtually  no  utility  in  predicting  function  or  immunosuppressive   13.  Krampera M, Galipeau J, Shi Y, et al: Immunological characterization
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          of  human  MSCs  with  interferon-γ  (IFN-γ)  markedly  potentiates  their   tissue-derived stromal/stem cells: a joint statement of the International
          immunosuppressive properties in vitro, and murine data support the   Federation for Adipose Therapeutics and Science (IFATS) and the Inter-
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          marker  of  suppressor  function,  it  has  been  shown  that  there  are   15.  Bernardo  ME,  Fibbe  WE:  Mesenchymal  stromal  cells:  sensors  and
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          from normal human donors and that the magnitude of IDO response   16.  Le  Blanc  K,  Mougiakakos  D:  Multipotent  mesenchymal  stromal  cells
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          may be substantially less potent than cells derived from high inducers.   17.  Ren  G,  Zhang  L,  Zhao  X,  et al:  Mesenchymal  stem  cell-mediated
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          For  example,  if  many  patients  receive  MSCs  derived  from  a  normal   18.  Nemeth K, Leelahavanichkul A, Yuen PS, et al: Bone marrow stromal
          volunteer  who  happens  to  be  a  low  IFN-γ  responder,  the  outcome   cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming
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          provide scientific rationale for selection of volunteer donors whose MSC
          deploys the greatest veto function and avoid the pitfalls of less potent   19.  Ren  G,  Su  J,  Zhang  L,  et al:  Species  variation  in  the  mechanisms  of
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