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Chapter 108  Graft-Versus-Host Disease and Graft-Versus-Leukemia Responses  1668.e5


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            192.  Drobyski WR, Gendelman M: Regulation of alloresponses after bone   214.  Nikolic B, Lee S, Bronson R, et al: Th1 and Th2 mediate acute graft-
                marrow  transplantation  using  donor  T  cells  expressing  a  thymidine   versus-host disease, each with distinct end-organ targets. J Clin Invest
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            193.  Drobyski WR, Klein J, Flomenberg N, et al: Superior survival associ-  215.  Carlson MJ, West ML, Coghill JM, et al: In vitro-differentiated TH17
                ated  with  transplantation  of  matched  unrelated  versus  one-antigen-  cells mediate lethal acute graft-versus-host disease with severe cutaneous
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                while  preserving  graft-versus-leukemia  effect  after  selective  depletion   graft-versus-host  disease  in  the  absence  of  the  transcription  factor
                of host-reactive T cells by photodynamic cell purging process. Blood   RORgammat. J Immunol 189(4):1765–1772, 2012.
                99:3083, 2002.                                    219.  Markey  KA,  MacDonald  KP,  Hill  GR: The  biology  of  graft-versus-
            196.  Byersdorfer CA, Tkachev V, Opipari AW, et al: Effector T cells require   host disease: experimental systems instructing clinical practice. Blood
                fatty  acid  metabolism  during  murine  graft-versus-host  disease.  Blood   124(3):354–362, 2014.
                122(18):3230, 2013.                               220.  Wysocki  CA,  Panoskaltsis-Mortari  A,  Blazar  BR,  et al:  Leukocyte
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                of alloreactive T cells causes their selective apoptosis and arrests graft-  221.  Cyster JG: Chemokines, sphingosine-1-phosphate, and cell migration
                versus-host disease. Sci Transl Med 3(67):67ra8, 2011.  in secondary lymphoid organs. Annu Rev Immunol 23:127, 2005.
            198.  Liu J, Farmer JD, Jr, Lane WS, et al: Calcineurin is a common target   222.  Serody  JS,  Burkett  SE,  Panoskaltsis-Mortari  A,  et al:  T-lymphocyte
                of  cyclophilin-cyclosporin  A  and  FKBP-FK506  complexes.  Cell   production of macrophage inflammatory protein-1alpha is critical to
                                                                                      +
                66(4):807–815, 1991.                                  the recruitment of CD8( ) T cells to the liver, lung, and spleen during
            199.  Blazar  BR, Taylor  PA,  Snover  DC,  et al:  Murine  recipients  of  fully   graft-versus-host disease. Blood 96:2973, 2000.
                mismatched donor marrow are protected from lethal graft-versus-host   223.  Mapara  MY,  Leng  C,  Kim  YM,  et al:  Expression  of  chemokines  in
                disease  by  the  in  vivo  administration  of  rapamycin  but  develop  an   GVHD target organs is influenced by conditioning and genetic factors
                autoimmune-like syndrome. J Immunol 151(10):5726–5741, 1993.  and  amplified  by  GVHR.  Biol  Blood  Marrow  Transplant  12:623,
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            201.  Mathewson N, Toubai T, Kapeles S, et al: Neddylation plays an impor-  donor T-cell migration in acute GVHD. Exp Hematol 31:897, 2003.
                tant role in the regulation of murine and human dendritic cell function.   225.  Wysocki  CA,  Burkett  SB,  Panoskaltsis-Mortari  A,  et al:  Differential
                Blood 122(12):2062–2073, 2013.                        roles for CCR5 expression on donor T cells during graft-versus-host
            202.  Sun Y, Wang Y, Toubai T, et al: BET bromodomain inhibition suppresses   disease based on pretransplant conditioning. J Immunol 173:845, 2004.
                graft-versus-host disease after allogeneic bone marrow transplantation   226.  Murai  M,  Yoneyama  H,  Harada  A,  et al:  Active  participation  of
                                                                          +
                                                                               +
                in mice. Blood 125(17):2724–2728, 2015.               CCR5( )CD8( ) T lymphocytes in the pathogenesis of liver injury in
            203.  Sun Y, Oravecz-Wilson K, Mathewson N, et al: Mature T cell responses   graft-versus-host disease. J Clin Invest 104:49, 1999.
                are  controlled  by  microRNA-142.  J  Clin  Invest  125(7):2825–2840,   227.  Wysocki  C,  Burkett  S,  Chwastiak  K,  et al:  CCR5  expression  on
                                                                              +
                                                                         +
                2015.                                                 CD4 CD25  regulatory T cells plays a critical role in their ability to
            204.  Ranganathan P, Heaphy CE, Costinean S, et al: Regulation of acute   prevent GVHD. Blood 102:#517, 2003.
                graft-versus-host disease by microRNA-155. Blood 119(20):4786–4797,   228.  Reshef R, Luger SM, Hexner EO, et al: Blockade of lymphocyte chemo-
                2012.                                                 taxis in visceral graft-versus-host disease. N Engl J Med 367(2):135–145,
            205.  Ayash LJ, Clarke M, Silver SM, et al: Double dose-intensive chemo-  2012.
                therapy with autologous stem cell support for relapsed and refractory   229.  Waldman  E,  Lu  SX,  Hubbard VM,  et al:  Absence  of  beta7  integrin
                testicular cancer: the University of Michigan experience and literature   results in less graft-versus-host disease because of decreased homing of
                review. Bone Marrow Transplant 27:939, 2001.          alloreactive T cells to intestine. Blood 107:1703, 2006.
            206.  Ferrara  JLM: The  cytokine  storm  of  acute  graft-versus  host  disease.   230.  Welniak LA, Kuprash DV, Tumanov AV, et al: Peyer’s patches are not
                Haematol Rev 8:27, 1994.                              required for acute graft-versus-host disease after myeloablative condi-
            207.  Reddy P: Pathophysiology of acute graft-versus-host disease. Hematol   tioning  and  murine  allogeneic  bone  marrow  transplantation.  Blood
                Oncol 21:149, 2003.                                   107:410, 2006.
            208.  Chen  X,  Das  R,  Komorowski  R,  et al:  Blockade  of  interleukin-6   231.  Kim YM, Sachs T, Asavaroengchai W, et al: Graft-versus-host disease
                signaling augments regulatory T-cell reconstitution and attenuates the   can  be  separated  from  graft-versus-lymphoma  effects  by  control  of
                severity of graft-versus-host disease. Blood 114:891, 2009.  lymphocyte trafficking with FTY720. J Clin Invest 111:659, 2003.
            209.  McDonald-Hyman C, Turka LA, Blazar BR: Advances and challenges   232.  Lee  RS,  Kuhr  CS,  Sale  GE,  et al:  FTY720  does  not  abrogate  acute
                in immunotherapy for solid organ and hematopoietic stem cell trans-  graft-versus-host  disease  in  the  dog  leukocyte  antigen-nonidentical
                plantation. Sci Transl Med 7(280):280rv2, 2015.       unrelated canine model. Transplantation 76:1155, 2003.
            210.  Teshima  T,  Maeda  Y,  Ozaki  K:  Regulatory  T  cells  and  IL-17-pro-  233.  Sallusto F, Mackay CR, Lanzavecchia A: The role of chemokine recep-
                ducing cells in graft-versus-host disease. Immunotherapy 3(7):833–852,   tors  in  primary,  effector,  and  memory  immune  responses.  Annu  Rev
                2011.                                                 Immunol 18:593, 2000.
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