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Chapter 136  Inhibitors in Hemophilias  2033.e1

            REFERENCES                                             25.  Pandev  GS,  Yanover  C,  Miller-Jenkins  LM,  et al  and  the  PATH
                                                                      Study Investigators: Synthesis of FVIII in Hemophilia A patients with
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                Assoc 57:223, 1941.                                26.  Astermark  J,  Oldenburg  J,  Pavlova  A,  et al:  Polymorphisms  in  the
             2.  Munro FL, Jones HW: The detrimental effect of frequent transfusions   IL-10  but  not  in  the  IL1Beta  and  IL4  genes  are  associated  with
                in the treatment of a patient with hemophilia. Am J Med Sci 206:710,   inhibitor development in patients with haemophilia A. Blood 107:3167,
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             3.  Munro  FL,  Munro  MP:  Electrophoretic  isolation  of  a  circulating   27.  van der Bom JG, Mauser-Bunschoten EP, Fischer K, et al: Age at first
                anticoagulant. J Clin Invest 25:814, 1946.            treatment and immune tolerance to factor VIII in severe hemophilia.
             4.  Munro  FL:  Properties  of  an  anticoagulant  found  in  the  blood  of  a   Thromb Haemost 89:475, 2003.
                hemophiliac. J Clin Invest 25:422, 1946.           28.  Goudemand J, Rothschild C, Demiguel V, et al: Influence of the type
             5.  Craddock  CG,  Jr,  Lawrence  JS:  A  report  of  the  mechanism  of  the   of factor VIII concentrate on the incidence of factor VIII inhibitors in
                development and action of an anticoagulant in two cases. Blood 2:505,   previously untreated patients with severe hemophilia A. Blood 107:46,
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             6.  Bidwell E, Denson KW, Dike GW: Antibody nature of the inhibitor   29.  Hay  CR:  The  epidemiology  of  factor  VIII  inhibitors.  Haemophilia
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             7.  Oldenburg J, Schroeder J, Brackmann HH, et al: Environmental and   30.  Santagostino  E,  Mancuso  ME,  Rocino  A,  et al:  Environmental  risk
                genetic  factors  influencing  inhibitor  development.  Semin  Hematol   factors for inhibitor development in children with haemophilia A: A
                41:82, 2004.                                          case-control study. Br J Haematol 130:422, 2005.
             8.  Schwaab R, Brackmann HH, Meyer C, et al: Haemophilia A: Mutation   31.  Varon D, Martinowitz U: Continuous infusion therapy in haemophilia.
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                1995.                                              32.  Sharathkumar A, Lillicrap D, Blanchette VS, et al: Intensive exposure to
             9.  Key NS: Inhibitors in congenital coagulation disorders. Br J Haematol   factor VIII is a risk factor for inhibitor development in mild hemophilia
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             10.  Ingerslev  J:  Hemophilia.  Strategies  for  the  treatment  of  inhibitor   33.  ter Avest PC, Fischer K, Mancuso ME, et al On behalf of the Canal
                patients. Haematologica 85:15, 2000.                  Study Group: Risk stratification for inhibitor development at first treat-
             11.  Hay  CRM,  Palmer  B,  Chalmers  E,  et al  on  behalf  of  the  United   ment for severe haemophilia A: a tool for clinical practice. J Thromb
                Kingdom  Hemophilia  Centre  Doctor’s  Organisation  (UKHCDO):   Haemost 6:2048, 2008.
                Incidence of FVIII inhibitors throughout life in severe haemophilia A   34.  Elalfy MS, Elbarbary NS, Eldebeily MS, et al: Risk of bleeding and
                in the United Kingdom. Blood 117:6367, 2011.          inhibitor  development  after  circumcision  of  previously  untreated  or
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                on subsequent mortality, 1977-99.                  35.  Lusher JM: Is the incidence and prevalence of inhibitors greater with
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                and causes of death in people with haemophilia A or B in the United   36.  Aledort LM: Is the incidence and prevalence of inhibitors greater with
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             14.  Astermark J, Berntorp E: Malmo International Brother Study (MIBS).   37.  Schwartz RS, Abildgaard CF, Aledort LM, et al: Human recombinant
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                77:80, 1999.                                          hemophilia A. Recombinant Factor VIII Study Group. N Engl J Med
             15.  Astermark J, Berntorp E, White GC, et al: The Malmo International   323:1800, 1990.
                Brother Study (MIBS): Further support for genetic predisposition to   38.  Bray GL, Gomperts ED, Courter S, et al: A multicenter study of recom-
                inhibitor  development  in  hemophilia  patients.  Haemophilia  7:267,   binant  factor VIII  (Recombinate):  Safety,  efficacy,  and  inhibitor  risk
                2001.                                                 in previously untreated patients with hemophilia A. The Recombinate
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                hemophilia A. In Hoyer LW, editor: Factor VIII Inhibitors: Proceedings of   39.  Lusher  J,  Abildgaard  C,  Arkin  S,  et al:  Human  recombinant  DNA-
                an International Symposium Held in Farmington, Connecticut, Springer   derived antihemophilic factor in the treatment of previously untreated
                Berlin, 1984, Heidelberg, p 19. November 3-5, 1983.   patients with hemophilia A: Final report on a hallmark clinical investi-
             17.  Addiego JE, Kasper CK, Abildgaard CF, et al: Increased frequency of   gation. J Thromb Haemost 2:574, 2004.
                inhibitors  in  African  American  hemophilia  A  patients  (abstr).  Blood   40.  Gruppo R, Chen H, Schroth P, et al: Safety and immunogenicity of
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             18.  Aledort  LM,  Dimichele  DM:  Inhibitors  occur  more  frequently  in   (PUPs): A 7.3 year update (abstr). XXIII Congress of the WFH, The
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                1998.                                              41.  Brinkhous K, Roberts HR, Weiss A: Prevalence of inhibitors in hemo-
             19.  Scharrer  I,  Bray  GL,  Neutzling  O:  Incidence  of  inhibitors  in  hae-  philia A and B. Thromb Diath Haemorrh Suppl 51:315, 1972.
                mophilia  A  patients:  A  review  of  recent  studies  of  recombinant  and   42.  Iorio A, Hallmeh S, Holzhauer S, et al: Rate of inhibitor development
                plasma-derived factor VIII concentrates. Haemophilia 5:145, 1999.  in  previously  untreated  hemophilia  A  patients  treated  with  plasma-
             20.  Viel KR, Ameri A, Abshire TC, et al: Inhibitors of factor VIII in black   derived or recombinant factor VIII concentrates: a systematic review.
                patients with hemophilia. N Engl J Med 360:1618, 2009.  J Thromb Haemost 8:1256, 2010.
             21.  Gouw SC, van den Berg HM, Oldenburg J, et al: F8 gene mutation   43.  Mauser-Bunschoten EP, vander Born JG, Bongers M, et al: Purity of
                type and inhibitor development in patients with severe haemophilia A:   factor VIII product and incidence of inhibitors in previously untreated
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             22.  Oldenburg J, Pavlova A: Genetic risk factors for inhibitors to factors   44.  Klukowska  A,  Komrska V,  Jansen  M,  et al:  Low  incidence  of  FVIII
                VIII and IX. Haemophilia 12S:15, 2006.                inhibitors  in  previously  untreated  patients  during  prophylaxis.  On
             23.  Oldenburg J, Schroder J, Brackmann HH, et al: Environmental and   demand and surgical procedures, with Octanate: interim report from
                genetic  factors  influencing  inhibitor  development.  Semin  Hematol   ongoing prospective clinical study. Haemophilia 17:399, 2011.
                41:82, 2004.                                       45.  Gouw SC, van der Born JG, Auerswald G, et al: Recombinant versus
             24.  Sauna  ZE,  Lozier  JN,  Kasper  CK,  et al: The  intron-22-inverted  F8   plasma-derived factor VIII products and the development of inhibitors
                locus permits factor VIII synthesis: explanation for low inhibitor risk   in previously untreated patients with severe haemophilia A: the CANAL
                and a role for pharmacogenomics. Blood 125:223–228, 2015.  Cohort Study. Blood 109:4693, 2007.
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