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2033.e2  Part XII  Hemostasis and Thrombosis


         46.  Franchini  M,  Tagliaferri  A,  Mengoli  C,  et al:  Cumulative  inhibitor   66.  Gilles JG, Arnout J, Vermylen J, et al: Anti-factor VIII antibodies of
            incidence  in  previously  untreated  patients  with  severe  haemophilia   hemophiliac  patients  are  frequently  directed  towards  nonfunctional
            A  treated  with  plasma-derived  versus  recombinant  factor  VIII  con-  determinants and do not exhibit isotypic restriction. Blood 82:2452,
            centrates: a critical systematic review. Crit Rev Oncol Hematol 81:82,   1993.
            2012.                                              67.  Hofbauer CJ, Whelan SF, Hirschler M, et al: Affinity of FVIII-specific
         47.  Maclean  PS,  Richards  M,  Williams  M,  et al:  Chalmers  EA  for  the   antibodies  reveals  major  differences  between  neutralizing  and  non-
            Paediatric Working Party of the UKHCDO. Treatment related factors   neutralizing antibodies in humans. Blood 125:1180–1188, 2015.
            and  inhibitor  development  in  children  with  severe  haemophilia  A.   68.  Hay CR, Ollier W, Pepper L, et al: HLA class II profile: A weak deter-
            Haemophilia 17:282, 2011.                             minant of factor VIII inhibitor development in severe haemophilia A.
         48.  Peerlinck K, Arnout J, Di Giambattista M, et al: Factor VIII inhibitors   UKHCDO Inhibitor Working Party. Thromb Haemost 77:234, 1997.
            in  previously  treated  haemophilia  A  patients  with  a  double  virus-  69.  Oldenburg J, Picard JK, Schwaab R, et al: HLA genotype of patients
            inactivated  plasma  derived  factor VIII  concentrate.  Thromb  Haemost   with severe haemophilia A due to intron 22 inversion with and without
            77:80, 1997.                                          inhibitors of factor VIII. Thromb Haemost 77:238, 1997.
         49.  Peerlinck K, Arnout J, Gilles JG, et al: A higher than expected incidence   70.  Lavigne-Lissalde  G,  Schved  JF,  Granier  C,  et al:  Anti-factor  VIII
            of  factor  VIII  inhibitors  in  multitransfused  haemophilia  A  patients   antibodies: A 2005 update. Thromb Haemost 94:760, 2005.
            treated with an intermediate purity pasteurized factor VIII concentrate.   71.  Astermark J, Wang X, Oldenburg J, et al on behalf of the MIBS Study
            Thromb Haemost 69:115, 1993.                          Group:  Polymorphisms  in  the  CTLA-4  gene  and  inhibitor  develop-
         50.  Rosendaal FR, Nieuwenhuis HK, van den Berg HM, et al: A sudden   ment in patients with severe haemophilia A. J Thromb Haemost 5:263,
            increase in factor VIII inhibitor development in multitransfused hemo-  2007.
            philia A patients in The Netherlands. Dutch Hemophilia Study Group.   72.  Astermark  J,  Oldenburg  J,  Pavlova  A,  et al:  Polymorphisms  in  the
            Blood 81:2180, 1993.                                  IL-10  but  not  in  the  IL-1β  and  IL-4  genes  are  associated  with
         51.  Giles AR, Rivard GE, Teitel J, et al: Surveillance for factor VIII inhibi-  inhibitor development in patients with hemophilia A. Blood 107:3167,
            tor development in the Canadian Hemophilia A population following   2006.
            the widespread introduction of recombinant factor VIII replacement   73.  Astermark J, Donfield SM, Gomperts ED, et al: The polygenic nature
            therapy. Transfus Sci 19:139, 1998.                   of inhibitors in hemophilia A: results from the Hemophilia Inhibitor
         52.  van den Berg HM, Chalmers EA: Clinical prediction models for inhibi-  Genetics Study (HIGHS) Combined Cohort. Blood 121:1445–1454,
            tor development in severe hemophilia A. J Thromb Haemost 7(Suppl   2013.
            1):98–102, 2009.                                   74.  Miao  CH:  Immunemodulation  for  inhibitors  in  haemophilia  A:  the
         53.  Gouw SC, van den Berg HM, Fischer K, et al: for the RODIN Study   important role of Treg cells. Expert Rev Hematol 3:469, 2010.
            Group. Intensity of factor VIII treatment and inhibitor development   75.  Lenting  PJ,  van  Mourik  JA,  Mertens  K:  The  life  cycle  of  coagula-
            in  children  with  severe  hemophilia  A:  the  RODIN  study.  Blood   tion factor VIII in view of its structure and function. Blood 92:3983,
            121:4046–4056, 2013.                                  1998.
         54.  Halimeh S, Bidkingmaier C, Heller C, et al: Risk factors of high-titre   76.  Saenko EL, Ananyeva NM, Tuddenham EG, et al: Factor VIII—Novel
            Inhibitor  development  in  children  with  hemophilia  A:  results  of  a   insights into form and function. Br J Haematol 119:323, 2002.
            cohort study. Biomed Res Int 901975:2013.          77.  Saenko EL, Scandella D: The acidic region of the factor VIII light chain
         55.  Fisher K, Lassila R, Peyvandi F, et al on behalf of the EUHASS: Inhibi-  and the C2 domain together form the high affinity binding site for von
            tor development in haemophilia according to concentrate. Four-year   Willebrand factor. J Biol Chem 272:18007, 1997.
            results  from  the  European  Haemophilia  Safety  Surveillance  project.   78.  Lollar  P,  Hill-Eubanks  DC,  Parker  CG:  Association  of  the  factor
            Thromb Haemost 113:2015.                              VIII light chain with von Willebrand factor. J Biol Chem 263:10451,
         56.  Peyvandi F, Mannucci PM, Garagiola I, et al: A randomized trial of   1988.
            FVIII  and  neutralizing  antibodies  in  hemophilia  A.  N  Engl  J  Med   79.  Shima M, Scandella D, Yoshioka A, et al: A factor VIII neutralizing
            374:2054–2064, 2016.                                  monoclonal antibody and a human inhibitor alloantibody recognizing
         57.  Hay CR, Palmer BP, Chalmers EA, et al: The incidence of factor VIII   epitopes  in  the  C2  domain  inhibit  factor VIII  binding  to  von Wil-
            inhibitors  in  severe  haemophilia  A  following  a  major  switch  from   lebrand  factor  and  to  phosphatidylserine.  Thromb  Haemost  69:240,
            full-length  to  B-domain-deleted  factor  VIII:  a  prospective  cohort   1993.
            comparison. Haemophilia 21:219–226, 2015.          80.  Saenko EL, Scandella D: A mechanism for inhibition of factor VIII
         58.  Carcao  MD:  More  on:  Intensive  factor  VIII  exposure  and  inhibi-  binding  to  phospholipid  by  von  Willebrand  factor.  J  Biol  Chem
            tor  development  in  mild  hemophilia  A.  J  Thromb  Haemost  2:677,   270:13826, 1995.
            2004.                                              81.  Saenko EL, Shima M, Gilbert GE, et al: Slowed release of thrombin-
         59.  Eckhardt CL, van Velzen AS, Petrs M, et al: for the INSIGHT Study   cleaved factor VIII from von Willebrand factor by a monoclonal and a
            Group. Factor VIII gene (F8) mutation and risk of inhibitor develop-  human antibody is a novel mechanism for factor VIII inhibition. J Biol
            ment in nonsevere hemophilia A. Blood 122:1954–1962, 2013.  Chem 271:27424, 1996.
         60.  Ivaskevicius V, Goldman G, Horneff S, et al: Inhibitor development   82.  Barrow RT, Healey JF, Jacquemin MG, et al: Antigenicity of putative
            and  management  in  three  non-severe  haemophilia  A  patients  with   phospholipid membrane-binding residues in factor VIII. Blood 97:169,
            T295A variant. Hamostaseologie 34(S1):9–12, 2014.     2001.
         61.  Hay  CR,  Dimichele  DM: The  principal  results  of  the  International   83.  Arai M, Scandella D, Hoyer LW: Molecular basis of factor VIII inhibi-
            Immune  Tolerance  Study:  a  randomized  dose  comparison.  Blood   tion by human antibodies. Antibodies that bind to the factor VIII light
            119:1335, 2012.                                       chain prevent the interaction of factor VIII with phospholipid. J Clin
         62.  White  GC,  2nd,  Kempton  CL,  Grimsley  A,  et al:  Cellular  immune   Invest 83:1978, 1989.
            responses in hemophilia: Why do inhibitors develop in some, but not   84.  Lollar P: Molecular characterization of the immune response to factor
            all hemophiliacs? J Thromb Haemost 3:1676, 2005.      VIII. Vox Sang 83:403, 2002.
         63.  Aalberse  RC:  Shcuurman  J.  IgG4  breaking  the  rules.  Immunology   85.  Lacroix-Desmazes S, Moreau A, Sooryanarayana, et al: Catalytic activ-
            105:9–19, 2002.                                       ity of antibodies against factor VIII in patients with hemophilia A. Nat
         64.  Reipert  BM:  Risky  business  of  inhibitors:  HLA  haplotypes,  gene   Med 5:1044, 1999.
            polymorphisms, and immune responses. Hematology Am Soc Hematol   86.  Lacroix-Desmazes S, Bayry J, Misra N, et al: The prevalence of pro-
            Educ Program 2014:372, 2014.                          teolytic antibodies against factor VIII in hemophilia A. N Engl J Med
         65.  Boylan  B,  Rice  AS,  Dunn  AL,  et al:  Characterization  of  the  anti-  346:662, 2002.
            factor VIII immunoglobulin profile in patients with hemophilia A by   87.  Lacroix-Desmazes S, Wootla B, Dasgupta S, et al: Catalytic IgG from
            use of fluorescenc-based immunoassay. J Thromb Haemost 13:47–53,   patients with hemophilia A inactivate therapeutic factor VIII. J Immunol
            2015.                                                 177:1355, 2006.
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