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2214 Part XIII Consultative Hematology
FUTURE DIRECTIONS Hiss RG: Evaluation of the anemic patient. In Laros RK, editor: Blood
disorders in pregnancy, Philadelphia, 1986, Lea & Febiger, p 1.
Management of the hematologic complications of pregnancy contin- Hytten F: Blood volume changes in normal pregnancy. Clin Haematol
ues to be a challenge. The physicians and patient involved all benefit 14:601, 1985.
from a multidisciplinary approach. In certain disorders, the manage- Institute of Medicine: Nutrition services in perinatal care, Washington, DC,
ment is clear and will likely remain unchanged in the future. In other 1992, National Academy Press.
disorders, treatment paradigms may shift as new treatments are dis- Klebanoff MA, Shiono PH, Selby JV, et al: Anemia and spontaneous preterm
covered for the nonpregnant patient. In all instances, further well- birth. Am J Obstet Gynecol 164:59, 1991.
designed studies will continue to advance evidence-based management Lieberman E, Ryan KJ, Monson RR, et al: Association of maternal hematocrit
of the pregnant patient. with premature labor. Am J Obstet Gynecol 159:107, 1988.
Lu ZM, Goldenberg RL, Oliver SP, et al: The relationship between maternal
hematocrit and pregnancy outcome. Obstet Gynecol 77:190, 1991.
SUGGESTED READINGS Milman N: Iron and pregnancy—a delicate balance. Ann Hematol 85:559,
2006.
Al RA, Unlubilgin E, Kandamir O, et al: Intravenous verses oral iron for Milman N, Agger AI, Nielson OJ: Iron status markers and serum erythropoi-
treatment of anemia in pregnancy: a randomized trial. Obstet Gynecol etin in 120 mothers and newborn infants: effect of iron supplementation
106:1335, 2005. and normal pregnancy. Acta Obstet Gynecol Scand 73:200, 1994.
Allen LH: Nutritional supplementation for the pregnant woman. Clin Obstet Murphy JF, O’Riordan J, Newcombe RG, et al: Relation of haemoglobin
Gynecol 37:587, 1994. levels in first and second trimesters to outcome of pregnancy. Lancet
Bothwell TH: Overview and mechanisms of iron regulation. Nutr Rev 1:992, 1986.
53:237, 1995. Perry GS, Yip R, Zyrkowski C: Nutritional risk factors among low-income
Casanueva E, Viteri FE, Mares-Galindo M, et al: Weekly iron as a safe pregnant US women: the Centers for Disease Control and Prevention
alternative to daily supplementation for nonanemic pregnant women. (CDC) Pregnancy Nutrition Surveillance System, 1979 through 1993.
Arch Med Res 12:674, 2006. Semin Perinatol 19:211, 1995.
Centers for Disease Control and Prevention (CDC): CDC criteria for anemia Romslo I, Haram K, Sagen N, et al: Iron requirement in normal pregnancy
in children and childbearing-aged women. MMWR Morb Mortal Wkly as assessed by serum ferritin, serum transferring saturation, and eryth-
Rep 38:400, 1989. rocyte protoporphyrin determinations. Br J Obstet Gynaecol 90:101,
Centers for Disease Control and Prevention (CDC): Recommendations to 1983.
prevent and control iron deficiency in the United States. MMWR Recomm Rothman D: Folic acid in pregnancy. Am J Obstet Gynecol 108:149, 1970.
Rep 47(RR-3):1, 1998. Scholl TO, Hediger ML: Anemia and iron-deficiency anemia: compilation
Chanarin I: Folate and cobalamin. Clin Haematol 14:729, 1985. of data on pregnancy outcome. Am J Clin Nutr 59(2 Suppl):492S, 1994.
Chanarin I, MacGibbon BM, O’Sullivan WJ, et al: Folic acid deficiency Scholl TO, Hediger ML, Fischer RL, et al: Anemia vs iron deficiency:
in pregnancy—the pathogenesis of megaloblastic anemia of pregnancy. increased risk of preterm delivery in a prospective study. Am J Clin Nutr
Lancet 2:634, 1959. 55:985, 1992.
Chanarin I, Rothman D: Further observations on the relation between iron Singh K, Fong YF, Arulkumaran S: Anaemia in pregnancy—a cross-sectional
and folate status in pregnancy. Br Med J 2:81, 1971. study in Singapore. Eur J Clin Nutr 52:65, 1998.
Cogswell ME, Parvanta I, Ickes L, et al: Iron supplementation during World Health Organization: The prevalence of anaemia in women: a tabulation
pregnancy, anemia, and birth rate: a randomized trial. Am J Clin Nutr of available information, ed 2, Geneva, 1992, World Health Organization.
78:773, 2003. Zhou LM, Yang WW, Hua JZ, et al: Relation of hemoglobin measured at
Council on Foods and Nutrition Committee on Iron Deficiency: Iron different times in pregnancy to preterm birth and low birth weight in
deficiency in the United States. JAMA 203:119, 1968. Shanghai, China. Am J Epidemiol 148:998, 1998.
Crowley JP: Coagulopathy bleeding in the parturient patient: recent informa-
tion has helped in the identification of individuals at special risk. R I Med
J 72:135, 1989. REFERENCES
Galloway R, McGuire J: Determinants of compliance with iron supplementa-
tion: supplies, side effects, or psychology? Soc Sci Med 39:381, 1994. For the complete list of references, log on to www.expertconsult.com.
Garn SM, Ridella SA, Petzold AS, et al: Maternal hematologic levels and
pregnancy outcomes. Semin Perinatol 5:155, 1981.

