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2214   Part XIII  Consultative Hematology

        FUTURE DIRECTIONS                                     Hiss  RG:  Evaluation  of  the  anemic  patient.  In  Laros  RK,  editor:  Blood
                                                                 disorders in pregnancy, Philadelphia, 1986, Lea & Febiger, p 1.
        Management of the hematologic complications of pregnancy contin-  Hytten  F:  Blood  volume  changes  in  normal  pregnancy.  Clin  Haematol
        ues to be a challenge. The physicians and patient involved all benefit   14:601, 1985.
        from a multidisciplinary approach. In certain disorders, the manage-  Institute of Medicine: Nutrition services in perinatal care, Washington, DC,
        ment is clear and will likely remain unchanged in the future. In other   1992, National Academy Press.
        disorders, treatment paradigms may shift as new treatments are dis-  Klebanoff MA, Shiono PH, Selby JV, et al: Anemia and spontaneous preterm
        covered for the nonpregnant patient. In all instances, further well-  birth. Am J Obstet Gynecol 164:59, 1991.
        designed studies will continue to advance evidence-based management   Lieberman E, Ryan KJ, Monson RR, et al: Association of maternal hematocrit
        of the pregnant patient.                                 with premature labor. Am J Obstet Gynecol 159:107, 1988.
                                                              Lu ZM, Goldenberg RL, Oliver SP, et al: The relationship between maternal
                                                                 hematocrit and pregnancy outcome. Obstet Gynecol 77:190, 1991.
        SUGGESTED READINGS                                    Milman N: Iron and pregnancy—a delicate balance. Ann Hematol 85:559,
                                                                 2006.
        Al  RA,  Unlubilgin  E,  Kandamir  O,  et al:  Intravenous  verses  oral  iron  for   Milman N, Agger AI, Nielson OJ: Iron status markers and serum erythropoi-
           treatment  of  anemia  in  pregnancy:  a  randomized  trial.  Obstet  Gynecol   etin in 120 mothers and newborn infants: effect of iron supplementation
           106:1335, 2005.                                       and normal pregnancy. Acta Obstet Gynecol Scand 73:200, 1994.
        Allen LH: Nutritional supplementation for the pregnant woman. Clin Obstet   Murphy  JF,  O’Riordan  J,  Newcombe  RG,  et al:  Relation  of  haemoglobin
           Gynecol 37:587, 1994.                                 levels  in  first  and  second  trimesters  to  outcome  of  pregnancy.  Lancet
        Bothwell  TH:  Overview  and  mechanisms  of  iron  regulation.  Nutr  Rev   1:992, 1986.
           53:237, 1995.                                      Perry GS, Yip R, Zyrkowski C: Nutritional risk factors among low-income
        Casanueva  E,  Viteri  FE,  Mares-Galindo  M,  et al:  Weekly  iron  as  a  safe   pregnant  US  women:  the  Centers  for  Disease  Control  and  Prevention
           alternative  to  daily  supplementation  for  nonanemic  pregnant  women.   (CDC) Pregnancy Nutrition Surveillance System, 1979 through 1993.
           Arch Med Res 12:674, 2006.                            Semin Perinatol 19:211, 1995.
        Centers for Disease Control and Prevention (CDC): CDC criteria for anemia   Romslo I, Haram K, Sagen N, et al: Iron requirement in normal pregnancy
           in children and childbearing-aged women. MMWR Morb Mortal Wkly   as assessed by serum ferritin, serum transferring saturation, and eryth-
           Rep 38:400, 1989.                                     rocyte  protoporphyrin  determinations.  Br  J  Obstet  Gynaecol  90:101,
        Centers for Disease Control and Prevention (CDC): Recommendations to   1983.
           prevent and control iron deficiency in the United States. MMWR Recomm   Rothman D: Folic acid in pregnancy. Am J Obstet Gynecol 108:149, 1970.
           Rep 47(RR-3):1, 1998.                              Scholl TO, Hediger ML: Anemia and iron-deficiency anemia: compilation
        Chanarin I: Folate and cobalamin. Clin Haematol 14:729, 1985.  of data on pregnancy outcome. Am J Clin Nutr 59(2 Suppl):492S, 1994.
        Chanarin  I,  MacGibbon  BM,  O’Sullivan  WJ,  et al:  Folic  acid  deficiency   Scholl  TO,  Hediger  ML,  Fischer  RL,  et al:  Anemia  vs  iron  deficiency:
           in pregnancy—the pathogenesis of megaloblastic anemia of pregnancy.   increased risk of preterm delivery in a prospective study. Am J Clin Nutr
           Lancet 2:634, 1959.                                   55:985, 1992.
        Chanarin I, Rothman D: Further observations on the relation between iron   Singh K, Fong YF, Arulkumaran S: Anaemia in pregnancy—a cross-sectional
           and folate status in pregnancy. Br Med J 2:81, 1971.  study in Singapore. Eur J Clin Nutr 52:65, 1998.
        Cogswell  ME,  Parvanta  I,  Ickes  L,  et al:  Iron  supplementation  during   World Health Organization: The prevalence of anaemia in women: a tabulation
           pregnancy, anemia, and birth rate: a randomized trial. Am J Clin Nutr   of available information, ed 2, Geneva, 1992, World Health Organization.
           78:773, 2003.                                      Zhou LM, Yang WW, Hua JZ, et al: Relation of hemoglobin measured at
        Council  on  Foods  and  Nutrition  Committee  on  Iron  Deficiency:  Iron   different times in pregnancy to preterm birth and low birth weight in
           deficiency in the United States. JAMA 203:119, 1968.  Shanghai, China. Am J Epidemiol 148:998, 1998.
        Crowley JP: Coagulopathy bleeding in the parturient patient: recent informa-
           tion has helped in the identification of individuals at special risk. R I Med
           J 72:135, 1989.                                    REFERENCES
        Galloway R, McGuire J: Determinants of compliance with iron supplementa-
           tion: supplies, side effects, or psychology? Soc Sci Med 39:381, 1994.  For the complete list of references, log on to www.expertconsult.com.
        Garn  SM,  Ridella  SA,  Petzold  AS,  et al:  Maternal  hematologic  levels  and
           pregnancy outcomes. Semin Perinatol 5:155, 1981.
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