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2246  Part XII:  Hemostasis and Thrombosis                   Chapter 131:  The Antiphospholipid Syndrome             2247




                    73.  Krikun G, Lockwood CJ, Wu XX, et al: The expression of the placental anticoagulant     104. Ames PR, Tommasino C, Iannaccone L, et al: Coagulation activation and fibrinolytic
                     protein, annexin V, by villous trophoblasts: Immunolocalization and in vitro regulation.   imbalance in subjects with idiopathic antiphospholipid antibodies—A crucial role for
                     Placenta 15:601–612, 1994.                            acquired free protein S deficiency. Thromb Haemost 76:190–194, 1996.
                    74.  Ueki H, Mizushina T, Laoharatchatathanin T, et al: Loss of maternal annexin A5 increases     105. Schousboe I, Rasmussen MS: Synchronized inhibition of the phospholipid medi-
                     the likelihood of placental platelet thrombosis and foetal loss. Sci Rep 2:827, 2012.  ated autoactivation of factor XII in plasma by beta 2-glycoprotein I and anti-beta 2-
                    75.  Wang X, Campos B, Kaetzel MA, Dedman JR: Annexin V is critical in the maintenance   glycoprotein I. Thromb Haemost 73:798–804, 1995.
                     of murine placental integrity. Am J Obstet Gynecol 180:1008–1016, 1999.    106. Sacre SM, Stannard AK, Owen JS: Apolipoprotein E (apoE) isoforms differentially
                    76.  Rand JH, Wu XX, Andree HA, et al: Pregnancy loss in the antiphospholipid-antibody   induce nitric oxide production in endothelial cells. FEBS Lett 540:181–187, 2003.
                     syndrome—A possible thrombogenic mechanism. N Engl J Med 337:154–160, 1997.    107. Yang XV, Banerjee Y, Fernandez JA, et al: Activated protein C ligation of ApoER2
                    77.  van Heerde WL, Poort S, van ‘t Veer C, et al: Binding of recombinant annexin V to   (LRP8) causes Dab1-dependent signaling in U937 cells. Proc Natl Acad Sci U S A 106:
                     endothelial cells: Effect of annexin V binding on endothelial-cell-mediated thrombin   274–279, 2009.
                     formation. Biochem J 302:305–312, 1994.              108. Shi T, Giannakopoulos B, Yan X, et al: Anti-beta2-glycoprotein I antibodies in complex
                    78.  Rand JH, Wu XX, Andree HAM, et al: Antiphospholipid antibodies accelerate plasma   with beta2-glycoprotein I can activate platelets in a dysregulated manner via glycopro-
                     coagulation by inhibiting annexin-V binding to phospholipids: A “lupus procoagulant”   tein Ib-IX-V. Arthritis Rheum 54:2558–2567, 2006.
                     phenomenon. Blood 92:1652–1660, 1998.                109. Lutters BC, Derksen RH, Tekelenburg WL, et al: Dimers of beta 2-glycoprotein I
                    79.  Rand JH, Wu XX, Quinn AS, et al: Human monoclonal antiphospholipid antibodies   increase platelet deposition to collagen via interaction with phospholipids and the apo-
                     disrupt the annexin A5 anticoagulant crystal shield on phospholipid bilayers: Evidence   lipoprotein E receptor 2′. J Biol Chem 278:33831–33838, 2003.
                     from atomic force microscopy and functional assay. Am J Pathol 163:1193–1200, 2003.    110. Graham A, Ford I, Morrison R, et al: Anti-endothelial antibodies interfere in apoptotic
                    80.  Rand JH, Wu XX, Lapinski R, et al: Detection of antibody-mediated reduction of   cell clearance and promote thrombosis in patients with antiphospholipid syndrome. J
                     annexin  A5  anticoagulant  activity  in  plasmas  of  patients  with  the  antiphospholipid   Immunol 182:1756–1762, 2009.
                     syndrome. Blood 104:2783–2790, 2004.                 111. Sammaritano LR: Significance of aPL IgG subclasses. Lupus 5:436–439, 1996.
                    81.  Wu XX, Pierangeli SS, Rand JH: Resistance to annexin A5 binding and anticoagulant     112. Salmon JE, Girardi G, Holers VM: Complement activation as a mediator of antiphos-
                     activity in plasmas from patients with the antiphospholipid syndrome but not with   pholipid antibody induced pregnancy loss and thrombosis. Ann Rheum Dis 61(Suppl 2):
                     syphilis. J Thromb Haemost 4:271–273, 2006.           ii46–ii50, 2002.
                    82.  Hanly JG, Smith SA: Anti-beta2-glycoprotein I (GPI) autoantibodies, annexin V bind-    113. Salmon JE, Girardi G: The role of complement in the antiphospholipid syndrome. Curr
                     ing and the anti-phospholipid syndrome. Clin Exp Immunol 120:537–543, 2000.  Dir Autoimmun 7:133–148, 2004.
                    83.  Tomer  A:  Antiphospholipid  antibody  syndrome:  Rapid,  sensitive,  and  specific  flow     114. Girardi G, Redecha P, Salmon JE: Heparin prevents antiphospholipid antibody-induced
                     cytometric assay for determination of anti-platelet phospholipid autoantibodies. J Lab   fetal loss by inhibiting complement activation. Nat Med 10:1222–1226, 2004.
                     Clin Med 139:147–154, 2002.                          115. Redecha P, Tilley R, Tencati M, et al: Tissue factor: A link between C5a and neutrophil
                    84.  Tomer A, Bar-Lev S, Fleisher S, et al: Antiphospholipid antibody syndrome: The flow   activation in antiphospholipid antibody induced fetal injury.  Blood 110:2423–2431,
                     cytometric annexin A5 competition assay as a diagnostic tool. Br J Haematol 139:113–  2007.
                     120, 2007.                                           116. Redecha P, Franzke CW, Ruf W, et al: Neutrophil activation by the tissue factor/Factor
                    85.  Gaspersic N, Ambrozic A, Bozic B, et al: Annexin A5 binding to giant phospholipid   VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome.
                     vesicles is differentially affected by anti-beta2-glycoprotein I and anti-annexin A5 anti-  J Clin Invest 118:3453–3461, 2008.
                     bodies. Rheumatology 46:81–86, 2007.                 117. Zhou H, Wolberg AS, Roubey RA: Characterization of monocyte tissue factor activity
                    86.  Rand JH, Wu XX, Guller S, et al: Reduction of annexin-V (placental anticoagulant   induced by IgG antiphospholipid antibodies and inhibition by dilazep. Blood 104:2353–
                     protein-I) on placental villi of women with antiphospholipid antibodies and recurrent   2358, 2004.
                     spontaneous abortion. Am J Obstet Gynecol 171:1566–1572, 1994.    118. Roubey RA: New approaches to prevention of thrombosis in the antiphospholipid
                    87.  Cederholm A, Svenungsson E, Jensen-Urstad K, et al: Decreased binding of annexin   syndrome: Hopes, trials, and tribulations. Arthritis Rheum 48:3004–3008, 2003.
                     V to endothelial cells: A potential mechanism in atherothrombosis of patients with     119. Martini F, Farsi A, Gori AM, et al: Antiphospholipid antibodies (aPL) increase the
                     systemic lupus erythematosus. Arterioscler Thromb Vasc Biol 25:198–203, 2005.  potential monocyte procoagulant activity in patients with systemic lupus erythematosus.
                    88.  Dueymes M, Levy Y, Ziporen L, et al: Do some antiphospholipid antibodies target   Lupus 5:206–211, 1996.
                     endothelial cells? Ann Med Interne (Paris) 147(Suppl 1):22–23, 1996.    120. Bu C, Gao L, Xie W, et al: Beta2-glycoprotein i is a cofactor for tissue plasminogen
                    89.  Del-Papa N, Raschi E, Catelli L, et al: Endothelial cells as a target for antiphospho-  activator-mediated plasminogen activation. Arthritis Rheum 60:559–568, 2009.
                     lipid antibodies: Role of anti-beta 2 glycoprotein I antibodies. Am J Reprod Immunol     121. Riewald M, Ruf W: Protease-activated receptor-1 signaling by activated protein C in
                     38:212–217, 1997.                                     cytokine-perturbed endothelial cells is distinct from thrombin signaling. J Biol Chem
                    90.  Matsuda J, Gotoh M, Gohchi K, et al: Anti-endothelial cell antibodies to the endothelial   280:19808–19814, 2005.
                     hybridoma cell line (EAhy926) in systemic lupus erythematosus patients with antiphos-    122. Niessen F, Furlan-Freguia C, Fernandez JA, et al: Endogenous EPCR/aPC-PAR1
                     pholipid antibodies. Br J Haematol 97:227–232, 1997.  signaling prevents inflammation-induced vascular leakage and lethality.  Blood 113:
                    91.  Navarro M, Cervera R, Teixido M, et al: Antibodies to endothelial cells and to beta   2859–2866, 2009.
                     2-glycoprotein I in the antiphospholipid syndrome: Prevalence and isotype distribu-    123. Nojima J, Kuratsune H, Suehisa E, et al: Acquired activated protein C resistance associ-
                     tion. Br J Rheumatol 35:523–528, 1996.                ated with IgG antibodies against beta2-glycoprotein I and prothrombin as a strong risk
                    92.  Simantov R, Lo SK, Gharavi A, et al: Antiphospholipid antibodies activate vascular   factor for venous thromboembolism. Clin Chem 51:545–552, 2005.
                     endothelial cells. Lupus 5:440–441, 1996.            124. de Laat B, Eckmann CM, van SM, et al: Correlation between the potency of a beta2-
                    93.  Meroni PL, Papa ND, Beltrami B, et al: Modulation of endothelial cell function by anti-  glycoprotein I-dependent lupus anticoagulant and the level of resistance to activated
                     phospholipid antibodies. Lupus 5:448–450, 1996.       protein C. Blood Coagul Fibrinolysis 19:757–764, 2008.
                    94.  Cockrell E, Espinola RG, McCrae KR: Annexin A2: Biology and relevance to the anti-    125. Hurtado V, Montes R, Gris JC, et al: Autoantibodies against EPCR are found in anti-
                     phospholipid syndrome. Lupus 17:943–951, 2008.        phospholipid syndrome and are a risk factor for fetal death.  Blood 104:1369–1374,
                    95.  Romay-Penabad Z, Montiel-Manzano MG, Shilagard T, et al: Annexin A2 is involved   2004.
                     in antiphospholipid antibody-mediated pathogenic effects in vitro and in vivo. Blood     126. Proulle V, Furie RA, Merrill-Skoloff G, Furie BC: Platelets are required for enhanced
                     114:3074–3083, 2009.                                  activation of the endothelium and fibrinogen in a mouse thrombosis model of APS.
                    96.  Raschi E, Borghi MO, Grossi C, et al: Toll-like receptors: Another player in the patho-  Blood 124:611–622, 2014.
                     genesis of the anti-phospholipid syndrome. Lupus 17:937–942, 2008.    127. Lin YL, Wang CT: Activation of human platelets by the rabbit anticardiolipin antibodies.
                    97.  Xie H, Sheng L, Zhou H, Yan J: The role of TLR4 in pathophysiology of antiphos-  Blood 80:3135–3143, 1992.
                     pholipid syndrome-associated thrombosis and pregnancy morbidity.  Br  J  Haematol     128. van Lummel M, Pennings MT, Derksen RH, et al: The binding site in (beta)2-glycopro-
                     164:165–176, 2014.                                    tein I for ApoER2′ on platelets is located in domain V. J Biol Chem 280:36729–36736,
                    98.  Brandt KJ, Fickentscher C, Boehlen F, et al: NF-kappaB is activated from endosomal   2005.
                     compartments in antiphospholipid antibodies-treated human monocytes.  J Thromb     129. Forastiero RR, Martinuzzo ME, Broze GJ: High titers of autoantibodies to tissue fac-
                     Haemost 12:779–791, 2014.                             tor pathway inhibitor are associated with the antiphospholipid syndrome. J Thromb
                    99.  Raschi E, Testoni C, Bosisio D, et al: Role of the MyD88 transduction signaling pathway   Haemost 1:718–724, 2003.
                     in endothelial activation by antiphospholipid antibodies. Blood 101:3495–3500, 2003.    130. Witztum JL, Horkko S: The role of oxidized LDL in atherogenesis: Immunological
                    100. Vega-Ostertag ME, Ferrara DE, Romay-Penabad Z, et al: Role of p38 mitogen-activated   response and anti-phospholipid antibodies. Ann N Y Acad Sci 811:88–96, 1997.
                     protein kinase in antiphospholipid antibody-mediated thrombosis and endothelial cell     131. Vaarala O: Antiphospholipid antibodies and atherosclerosis. Lupus 5:442–447, 1996.
                     activation. J Thromb Haemost 5:1828–1834, 2007.      132. Lopez LR, Kobayashi K, Matsunami Y, Matsuura E: Immunogenic oxidized low-density
                    101. Cesarman-Maus G, Rios-Luna NP, Deora AB, et al: Autoantibodies against the fibrino-  lipoprotein/beta2-glycoprotein i complexes in the diagnostic management of athero-
                     lytic receptor, annexin 2, in antiphospholipid syndrome. Blood 107:4375–4382, 2006.  sclerosis. Clin Rev Allergy Immunol 37:12–19, 2009.
                    102. Chen PP, Yang CD, Ede K, et al: Some antiphospholipid antibodies bind to hemostasis     133. Canaud G, Bienaime F, Tabarin F, et al: Inhibition of the mTORC pathway in the anti-
                     and fibrinolysis proteases and promote thrombosis. Lupus 17:916–921, 2008.  phospholipid syndrome. N Engl J Med 371:303–312, 2014.
                    103. Cugno M, Cabibbe M, Galli M, et al: Antibodies to tissue-type plasminogen activator     134. Krnic BS, O’Connor CR, Looney SW, et al: A retrospective review of 61 patients with
                     (tPA) in patients with antiphospholipid syndrome: Evidence of interaction between the   antiphospholipid syndrome. Analysis of factors influencing recurrent thrombosis. Arch
                     antibodies and the catalytic domain of tPA in 2 patients. Blood 103:2121–2126, 2004.  Intern Med 157:2101–2108, 1997.





          Kaushansky_chapter 131_p2233-2252.indd   2247                                                                 9/18/15   5:10 PM
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