Page 2389 - Williams Hematology ( PDFDrive )

2360 Part XIII: Transfusion Medicine Chapter 137: Human Leukocyte and Platelet Antigens 2361

TABLE 137–4. Human Platelet Alloantigens 127,136,163*
Phenotypic Frequency Glycoprotein Location/ Encoding Gene/
Alloantigens Other Names (Whites) Amino Acid Substitution Nucleotide Change
HPA1a PlA, Zw 72% a/a GPIIIa ITGB3
HPA1b 26% a/b L33P T176C
HPA-1c 2% b/b L33V C175G
<1% a/c
HPA2a Ko, Sib 85% a/a GPIbα GPIBA
HPA2b 14% a/b T145M C482T
1% b/b
HPA3a Bak, Lek 37% a/a GPIIb ITGA2B
HPA3b 48% a/b I843S T2621G
15% b/b
HPA4a Pen, Yuk >99.9% a/a GPIIIa ITGB3
HPA4b <0.1% a/b R143Q G506A
<0.1% b/b
HPA-5a (Brb) Br, Hc, Zav 80% a/a GPIa ITGA2
HPA-5b (Bra) 19% a/b E505K G1600A
1% b/b
HPA-6bw Caa, Tu <1% GPIIIa ITGB3
R489Q G1544A
HPA-7bw Mob <1% GPIIa ITGB3
P407A C1297G
HPA-8bw Sra <0.1% GPIIIa ITGB3
R636C C1984T
HPA-9bw Maxa <1% GPIIb ITGA2B
V837M G2602A
HPA-10bw Laa 1% GPIIIa ITGB3
R62Q G263A
HPA-11bw Groa <0.5% GPIIIa ITGB3
R633H G1976A
HPA-12bw Iya 1% GPIbβ GPIBB
G15E G119A
HPA-13bw Sita <1% GPIa ITGA2
T799M C2483T
HPA-14bw Oea 1% GPIIIa ITGB3
K611del 1909_1911delAAG
HPA-15a Gov 35% a/a CD109 CD109
HPA-15b 42% a/b S682Y C2108A
23% b/b
HPA-16bw Duva <1% GPIIIa ITGB3
T140I C497T
HPA-17bw Vaa <1% GPIIIa ITGB3
T195M C662T
HPA-18bw <1% GPIa ITGA2
Q716H G2235T
HPA-19bw <1% GPIIIa ITGB3
K137Q A487C
(continued )

Kaushansky_chapter 137_p2353-2364.indd 2360 9/21/15 3:50 PM