Page 2464 - Williams Hematology ( PDFDrive )

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2434 Index Index 2435

for disseminated intravascular coagulation, γ-carboxyl glutamic acid (Gla) domain, in mantle cell lymphoma, 1593, 1593f,
2213 1915–1918, 1917f, 1918f, 1919f 1654
Friend of GATA (FOG), 271, 483–484 γδ heterodimers, 1175–1176 monocytosis and, 1097
Frizzled related protein-2 (FRP-2), 1738, γδ T cells, 1142, 1142t pernicious anemia and, 600
1739f γδ T-cell receptors, 1177, 1565, 2286 primary lymphomas, 1581
Fructose-1,6-biphosphate, 192 γ-globin chains, 728 in thrombotic thrombocytopenic purpura,
Fructose-1,6-diphosphate, 694, 695 β-thalassemias and production of, 742 2255
Fructose-6-diphosphate, 696, 696f developmental changes in synthesis of, 730 in Waldenström macroglobulinemia, 1791
Fructose-6-phosphate, 192, 694 fetal hemoglobin, 760 GATA-1
Fumarate hydratase (FH), 193 thalassemias and, 740 ALAS expression and, 893
Functional decline, coagulation and, 135 γ-heavy-chain disease, 1803–1806, 1804t, in biosynthesis of neutrophil granules,
Fungal infections 1805f 1011
in chronic lymphocytic leukemia, 1541 γ-retroviral vectors, 439 eosinophils and, 949
empiric therapy, 385–388, 387–388t Ganciclovir in erythropoiesis, 483
after hematopoietic cell transplantation, adverse effects, 1252, 1269 erythropoietin secretion and, 550
369 for CMV infection, 369, 1269 in hematopoiesis, 271, 2060
in immunocompromised host, 383 as empiric therapy for infections, 386, 387t in hematopoietic tissue, 730
pattern-recognition signaling pathways prophylactic, 389 in megakaryopoiesis, 1817, 1818, 1820
with increased susceptibility to, suicide gene activation by, 440 neutrophil granules and, 926
1230 Gas 6 (growth arrest-specific 6) protein, 484, in primary myelofibrosis, 1320
prevention, 389 1845 PU.1 and, 268
purpura and, 2104–2105, 2105f Gastrectomy, 601, 604, 1665 GATA-1, 539, 568, 2060
Furosemide Gastritis, 629 GATA2, 258, 262, 483–484, 949, 1215t, 1231,
for acute hemolytic transfusion reactions, Gastrointestinal tract 1606
2375 absorption GATA2, 1089, 1098, 1345, 1346t, 1351–1352,
vasculitis induced by, 2106, 2106f of cobalamin, 591–592 1379
Fusion proteins, 169–170, 1016–1017 of folate, 586–587, 587f GATA-3, 1156, 1180, 1181f
FUT, 2337 of iron, 552 GATA transcription factor family, 262
FVIII, 442 macrophages in, 1082 Gating strategies, 36
Fy(a-b-) phenotype, 2339 microbiome, 2287 Gaucher cells, 1126–1127, 1126f
mucosa, iron transport across, 619, 620f Gaucher disease, 1121–1128
G in pernicious anemia, 583, 600–601, 601f clinical features, 1123–1125, 1123t, 1125f
G /S checkpoint, 219 Gastrointestinal tract bleeding course and prognosis, 1128
1
G /M checkpoint, 219 anemia from, 553 differential diagnosis, 1127
2
G6PC3, 993 in hemophilia, 2120 epidemiology, 1121–1122
G6PD. See under Glucose-6-phosphate history of, 5 etiology and pathogenesis, 1122, 1122f
dehydrogenase iron deficiency and, 628–629, 628t gammopathy in, 1725
G20210A, 1920 in polycythemia vera, 1293 genetic basis, 1122–1123
GAGs (glycosaminoglycans), 69, 2027f, 2028 red cell transfusion for, 2370, 2370t heterozygote detection, 1127
Gaisböck syndrome, 872 Gastrointestinal tract disorders history and definition, 1121
Galactokinase, 692t, 701t in acute myelogenous leukemia, 1380– laboratory features, 635, 1124f, 1125–1127,
Galactose-1-P-uridyltransferase, 701t 1381, 1387 1126f
Galactose-4-epimerase, 692t in AL amyloidosis, 1760 pathophysiology, 1091
Galectin-1, 1182 in α-heavy-chain disease, 1806, 1808 therapy, 1127–1128, 1128f
Gallbladder disease in antiphospholipid syndrome, 2240 types, 1123, 1123t
in hereditary spherocytosis, 674 cobalamin deficiency and, 601 “Gaucheroma,” 1124, 1124f
primary lymphomas, 1581 eosinophils and, 955t, 956 GCL (glutamate cysteine ligase) deficiency,
in sickle cell disease, 772 folic acid deficiency and, 597 705
Gαi, 1875 gastric MALT lymphoma, 1664–1666, GCNT2, 2337
Gαi deficiency, 2057 1665f, 1666t G-CSF. See Granulocyte colony-stimulating
1
Gαq deficiency, 2057 in hemolytic uremic syndrome, 2258 factor (G-CSF)
Gαs, genetic variation in extra large, 2057 history of, 5 GDF15, 567
Gαs hyperfunction, 2057 immunoproliferative small intestinal GEF (guanine-nucleotide exchange factor),
Gαz, 1876 disease, 1663, 1665, 1808, 1809 1063f
GALT (gut-associated lymphoid tissue), inflammatory bowel disease, 1229 Gelatinase, 1012t, 1014
93–94, 94f in Langerhans cell histiocytosis, 1105 Gelatinase granules, 1009

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