Page 628 - Clinical Immunology_ Principles and Practice ( PDFDrive )

604 Part FIVE Allergic Diseases

Order Diptera Hemiptera Siphonaptera

Family Culicidae Simuliidae Tabanidae etc Triatomidae Cimicidae Pulicidae

Species Mosquito Blackfly Horsefly, deer fly Kissing bug Bed bug Human flea
Example Aedes, culex, anopheles Simulium Tabanus Triatoma protracta Cimex lectularius Pulex irritans
FIG 43.3 Biting insects that may cause allergic reactions.

TABLE 43.2 allergens of Hymenoptera Venoms

allergen Molecular Weight (kDa) Glycosylation Major/Minor allergen a Expressed as recombinant
allergens in Bee Venom (Apis mellifera)
Phospholipase A2 16 Yes Major Yes
Api m1
Hyaluronidase 45 Yes Major Yes
Api m2
Acid phosphatase 49 Yes Major Yes
Api m3
Melittin 2.8 No Minor Yes
Api m4
Dipeptidylpeptidase 102 Yes Major Yes
Api m5
Trypsin inhibitor 8 No Minor Yes
Api m6
CUB serine protease 39 Yes Major? Yes
Api m7
Carboxylesterase 70 Yes Minor
Api m8
Carboxypeptidase 60 Yes Minor
Api m9
Icarapin 29 Yes Major Yes
Api m10
MRJP8 b 65 Yes ?
Api m11.0101 60 Yes
MRJP9
11.0201
Vitellogenin 200 Yes ?
Api m12
allergens of Wasp/Yellow Jacket (Vespula spp., Ves v) and ant (Solenosis invicta, Sol i), Myrmecia pilosula,
(Myr p) Venoms
Vespula Vulgaris
Phospholipase A1 34 No Major Yes
Ves v1
Hyaluronidase 45 Yes Minor Yes
Ves v2
Dipeptidylpeptidase 100 Yes ? Yes
Ves v3
Antigen 5 23 No Major Yes
Ves v5
Vitellogenin 200 Yes
Ves v6
Solenopsis Invicta
Phospholipase A1 37 Yes Major Yes
Sol i1
Sol i2 14 No Minor
Antigen 5 26 Yes Major Yes
Sol i3
Sol i4 12 No Minor
Myr p1 6.1 Minor
Myr p2 5.6 Major
Myr p3 8.2 Minor
a Major allergen: ≥50% of allergic patients have specific immunoglobulin E (IgE) against. Minor allergen: <50% of allergic patients have specific IgE against.
b MRJP, major royal jelly protein.