Page 160 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

144 PART 2 ■ Hematopoiesis and Cellular Maturation

D m - Acanthocytes (F . . ) m , k - k

m j -

m m . I m , m m m z . U k ,

x m m k . H , . A

k : abetalipoproteinemia,

m m m . E k , m . I -

m m m , m

m m m . T m

( . ). T m -

. . T m ,

TABLE 7.2 Red Blood Cell Morphology and Related Conditions

Associated Clinical Associated Clinical

RBC Morphology Conditions RBC Morphology Conditions

Variation in size Pyknocytes Acute, severe hemolytic

anemias

Anisocytosis Signi cant in severe anemias G6PD de ciency

Macrocytes Megaloblastic anemias and Hereditary lipoprotein

macrocytic anemias (perni- de ciency

cious anemia and folic acid

de ciency)

May be seen in small numbers

during the rst 2–3 months of life

as infantile pyknocytes

Microcytes Iron de ciency anemia Schistocytes (schizocytes) Hemolytic anemias related to

burns or prosthetic implants

Hemoglobinopathies

Variation in shape Renal transplant rejection

Acanthocytes Abetalipoproteinemia Sickle cells (drepanocytes) Sickle cell anemia

Cirrhosis of the liver with asso- Spherocytes ABO hemolytic disease of the

ciated hemolytic anemia newborn

Following heparin administration Acquired hemolytic anemias

Hepatic hemangioma Blood transfusion reactions

Neonatal hepatitis Congenital spherocytosis

Postsplenectomy DIC

Blister cells An indication of pulmonary Storage phenomenon produc-

emboli in sickle cell anemia ing microspherocytes in the

recipient

Microangiopathic hemolytic

anemia

Burr cells (echinocytes) A variety of anemias Stomatocytes Acute alcoholism

Bleeding gastric ulcers Alcoholic cirrhosis

Gastric carcinoma Glutathione de ciency

Peptic ulcers Hereditary spherocytosis

Renal insuf ciency Infectious mononucleosis

Pyruvate kinase de ciency Lead poisoning

Uremia Malignancies

Thalassemia minor