Page 299 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

CHAPTER 15 ■ Macrocytic and Megaloblastic Anemias 283

A m Vitamin B (Cobalamin)
12

m C m z

mm . m . M m m
A x m % - B . T m B

m m . T , m . T m

- m , m W ( µ / ) m

q m j . I f m m q m . T

m mm , m m . I k

m

m m j m m- m .

x (MHC).

P m m mm Vitamin B (Cobalamin) Transport

mm . 12

T mm C m m -

(H m ’ ), - m - m

, A ’ , m , m q :

m, G ’ , m . I (IF)

. . m II ( C II)

. R

Physiology
IF, , z

N m m m m - m

, m B z m m m mm , m .

( m ) . M I , m IF m

. x q q m

V m B m z m m . A H, m

m , k m , k m m IF m

z m m m -IF m x (F . . ). B IF x -

m m . I

m m . m m . T m x m

A ’ , µ m. I m,

. m B m -IF m x -

x m µ / . A q µ m m m

m B , .

. A - T m x m m

m µ . q C II. C II

Dietary intake Fundus region FIGURE 15.2 V m B .

of vitamin B 12 (secretion of intrinsic factor [IF])

and folates

B 12 and

folate Stomach
(B ) Liver
12

Duodenum

(vitamin B + IF)
12
Transport
Transcobalamins

Transcobalamin II + B 12
Transcobalamin II
Jejunum

(B + IF)
12
B 12

Ileum

IF Reticulocytes