Page 304 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

288 PART 4 ■ Erythrocyte Disorders

TABLE 15.4 Folic Acid Assays Re ect Conditions

Normal Reference De ciency

Assay Range Negative Balance Depleted Stores in Tissues Anemia

Serum folic acid (ng/mL) 5–20 <3 <3 <3 >3

RBC folic acid (ng/mL) >200 >200 <200 <200 <200

Serum homocysteine (µmol/L) 5–15 5–15 5–15 15–250 15–250

Hypersegmentation of None None None 1+ 2+

neutrophils

MCV (fL) 80–95 80–95 80–95 90–110 100–130

Hemoglobin (g/dL) 12–15 12–15 12–15 12–15 <12

MCV mean cell volume; MMA, methylmalonic acid; RBC, red blood cell
,

CHAP ER HIGHLIGH S ■ N m m m B

z m . M

Macrocytic Anemias .

■ P m q m
■ M , m m .

(MCV), m m ■ T m x m

m m x m m ( k m ) m

m .

■ M m z .

m m m ■ C MCV, -

m . m , m MCV m .

■ N m m m k mm ■ P m .

. ■ T m -

■ T MCV m L. k , .

■ R , H -
Megaloblastic Anemias J , C m .

■ T m m m m ■ A m k m m
(m )
( ).

DNA . T % -

■ R m m m ■ m . S q m B m ,

m m m
m m . IF, %

■ M m m j .

, m C m mm -

m . ■ m .

■ T m m IF x m %

m B . H , ■ m . M

m m ( %) . I

m .
, m

m .
Pernicious Anemia

■ P m mm -
IF . Folic Acid De ciency Anemia

■ A m - ■ F
m ,

m z , m

mm k m m m

. .