Page 330 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

314 PART 4 ■ Erythrocyte Disorders

β 2 β 1

BOX 17.1

Percentage of Eastern Mediterranean Region

with an Abnormal Hemoglobin *

Proportion Country of Population

>10% Cyprus (17%), Bahrain (13%)

6%–10% Iraq, Morocco, Oman, Qatar, Saudi

Arabia, Sudan, Syria, Yemen

4%–6% Iran, Kuwait, Lebanon, Libya, Pakistan,

Tunisia, United Arab Emirates

α 2 α 1 <4% Afghanistan, Ethiopia, Egypt, Jordan

FIGURE 17.1 S m . (R m *
P CM. Pathophysiology Concepts o Altered Health States, T m m z -

, P , PA: L W m & W k , , m , x m , G PD, m m . D
m A M .
m .)

HEMOGLOBIN DEFEC S Demographics

SCD β thalassemias m mm m

A m m m sickle m . T “m ”
cell disease (SCD) m m , m . x m M ( B x . ) -

P m m m z (S/S) S A S A C .

z (S/A) trait. T k m T m m

m C, E, D, SC, SE, z -

SD . I m S, Plasmodium alciparum.

m m m m T k m q -

x C A . T m m j

m . T m k M . T m mm

k x N Am ,

m S m z m - m . T M E ,

m m m S A , O α m

m x . A m .

m S m SCD mm m -

m m m S -S A , S Am , C ,

. I m m C, m C Am , S A , I , M

m m x k , G , I . I U

m . S , , , m -

A m m m m A . T

q m m A A Am , ,

F . . H Am . A m Am ,

m m A Am , k .

m B A H -

- - . m U.S. ,

m x m -

.

Normal hemoglobin Glu Beta chain T m -
k m

m , .

Hemoglobin S Val Beta chain Etiology

FIGURE 17.2 C m m k m m - H m , x m , SCD, -

. (G , m ; V , .) m q