Page 400 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

384 PART 6 ■ Neoplastic Disorders

BOX 21.1

World Health Organization (WHO) Classi cation* of Acute Leukemias and Related Neoplasms

ACUTE MYELOID LEUKEMIA WITH RECURRENT AML m (M )

GENETIC ABNORMALITIES A m m k m (M )

P -AML ( ; )(q ;q ); RUNX1- A m /m k m (M )

RUNX1 1 A k m (M )

AML ( )( . q ) ( ; )( . ;q ); CBEB- P k m (M )

MYH11 E k m , /m (M )

AML ( ; )( ;q ); MLL 3-MLL A m k k m (M )

AML ( ; )( ;q ); DEK-NUP214 A k m

AML ( )(q q . ) ( ; )(q ;q . ); RPN1-EVI1 A m m

(NEW m GA A2 MYELOID SARCOMA

m RPN1 , q Myeloid Proliferations Related to Dow n’s

MECOM(EVI) q . . Syndrome

AML (m k ) ( ; )( ;q ); RBM15- m m

MKL1 M k m D ’ m

E : AML m NPM1

E : AML m CEBPA Blastic Plasmacytoid Dendritic Cell Neoplasm

AML m m - Acute Leukemias of Ambiguous Lineage

m m AML - A k m

. P m x k m

A P m L k m (APL) ( ; ) ( ; )(q ;q . ); BCR-ABL1

(q ;q ); PML-RARA M x k m ( ; q ); MLL

AML WITH MYELODYSPLASIA-RELATED CHANGE

THERAPY-RELATED MYELOID NEOPLASMS M x k m , B-m , NOS

AML, NOT OTHERWISE SPECIFIED AML-NOS M x k m , -m , NOS

U AML (M ) P : k (NK) m

AML m m (M ) k m / m m

AML m (M ) S : F K. CSP 2015 Short Course—Leukemia Classi cation 2016:

What, When, “Who,” C S P , S D , CA,
.
*
T W H O z . Classi cation o umors o the He-
matopoietic and Lymphoid issues, , L , F
.

ACU E MYELOID LEUKEMIAS m

k m .

Clonal Heterogeneity

Epidemiology
AML -

z m k m AML m mm k m -

q m m - m , U S

m m m - , (F . . ). C AML -

, . m

M AML z - — -

m m .

. Next-generation M % AML x -

sequencing (NGS) m q - m m . R m

x k m m . . P

V relapse AML, x ,

. C m - - m

m m mm m .