Page 419 - Clinical Hematology_ Theory _ Procedures ( PDFDrive )

CHAPTER 21 ■ Acute Leukemias 403

Monoclonal Antibodies Imm m m

k m q -
Im m unophenotyping .

Imm m m T m CD

k m (B ) CD ( ) m m m k . P

q . I m m B x , CD , CD B-

m k , m z , m . I , CD

m m - .

k m m m I , CD , , CD x

( . ). mm -

D , m . R

m z - m m m m .

m m x m A - CD - m

k m . T m j ALL x - m B- ALL .

m B- m

; m m x . B-Lineage Markers

T mm m m m k CD m q CD

m . R B-ALL. CD m j

- k m m - B- ALL -ALL. CD

, f . m B- ALL.

T-Lineage Markers

CD - ALL. O -
Monoclonal Antibodies Used —CD , CD , CD , CD —

TABLE 21.18 in Leukemia and Lymphoma .

Identi cation
B-Cell Markers

Cluster Cell Type B- m (F . . ) -B,

CD1a T -B, m B- . T m k
-B CD . T m B -
CD2 T
mm (SI ). T

CD3 T mm ALL

CD4 T . B

CD5 T B- m
CD CD , m ALL -
CD7 T
. T CD m k m -
CD8 T m B- m k m (B-CLL),

CD10 B B- m m , B- k m x ALL, -CLL

CD11b M/G Séz ’ m , AML, CML .

CD11c M/G precursors
Other Surface Membrane Markers
CD13 G/M (most G, some M)

CD14 M, some G O m m m k
m m , m m , m
CD19 B
B- m . T HLA-DR m k

CD20 B .

CD21 B

CD22 B

CD25 T LIFE- HREA ENING EMERGENCIES

CD33 G T m mm - m

CD41 Megakaryocytes and platelets k m

CD42b Megakaryocytes and platelets I

CD45 Various cells B
L k m
CD, cluster designation; T, T lymphocyte; B, B lymphocyte; M, monocytes; M m

G, granulocytes.
H k