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CHAPTER 19 MATURE LYMPHOPROLIFERATIVE DISORDERS 191
HAIRY CELL LEUKEMIA
A B
FIGURE 19–3A (PB 3500). FIGURE 19–3B (PB 31000).
D
C FIGURE 19–3D (BM 31000).
FIGURE 19–3C (BM 3500).
MORPHOLOGY
Peripheral Blood: Small- to medium-sized lymphocytes, reniform to oval nucleus with diffuse
homogeneous chromatin, 6 nucleolus, cytoplasm irregular, and gray-blue hairlike projections
Pancytopenia
Bone Marrow: Aspirate difficult to obtain because of marrow fibrosis (dry tap), cells more easily
distinguished by phase or electron microscopy
IMMUNOPHENOTYPE
CD19 , CD20 , CD22 , CD11c , Annexin A1 1
1
1
1
1
