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110                                HIGHSMITH ET AL.



      anti-gravity training system, or a virtual reality system   General Statements
      that provides real-time visual feedback. Two out of     Due to the high variability of gait training meth-
      the three articles to support this statement were case   ods identified in the literature, a clear pattern of the
      studies (12,36), making current evidence to support   most beneficial method of gait training was not able
      this statement low. Also, the finding that treadmill   to be identified. Conversely, the literature revealed
      training is the superior gait training modality to   a high level of evidence to support that any of the
      improve bioenergetic efficiency is misleading, as none   therapeutic gait training programs administered
      of the studies that included traditional overground   under skilled supervision that increases time spent
      gait training methods measured energy consump-  performing ambulatory activities beyond the patient’s
      tion or expenditure as a primary outcome measure.   current functional daily ambulation was effective at
      This is most likely explained by the convenience of   improving walking function in lower limb amputees
      measuring O2 consumption and gas exchange while   (6,11,12,16,17,19,25-36). Most studies assessed spa-
      participants are relatively fixed on a treadmill versus   tiotemporal, joint kinematics, bioenergetic efficiency,
      collecting this data while they ambulate over ground.   outcome measures, level of assistance, or a combina-
      Even so, it is unable to be determined at this time if   tion of these to demonstrate improvements in gait.
      improved bioenergetics can also be achieved with   Subsequently, evidence statements were able to be
      overground training methods or if this finding is lim-  formed. It is also important to note that adverse or
      ited to treadmill training. Therefore, future research   safety issues were not reported in connection with
      is recommended.                               the gait training methods studied.
        Lamberg et al. compared the effects of body-
      weight support treadmill training versus treadmill   Spatiotemporal Gait Parameters
      training without body-weight support (35). They     Current literature supports a high level of evidence
      found that treadmill training with and without body-  that therapeutic gait training methods, including
      weight support is effective to improve six-minute   early ambulation with a walking aid (32); in-shoe
      walk test distance and timed up and go test time;   auditory feedback  devices  (6,26);  psychological
      increase treadmill speed; and improve spatiotem-  awareness training (11); or treadmill training with or
      poral parameters for lower limb amputees with no   without body-weight support (34,35), or as a part of a
      significant differences found between groups. This   structured home exercise plan, are effective to reduce
      study reflects similar findings in patients post-stroke   spatiotemporal gait deviations. Lower limb amputees
      as published in a recent Cochrane review, which   demonstrate impaired spatiotemporal gait parame-
      concluded that treadmill training with or without   ters, including decreased prosthetic limb stance phase
      body weight support is effective to improve walking   duration, decreased intact limb step length, decreased
      speed and endurance (43). These findings have also   cadence, and decreased self-selected walking speed
      been demonstrated in patients with Parkinson’s dis-  compared to a healthy population (7,47). Changes in
      ease (44), traumatic brain injury (45), and in some   spatiotemporal gait parameters can lead to reduced
      patients following orthopedic surgery (46). All of   energy efficiency (42) and increased joint stress of
      these studies demonstrated carryover to overground   intact limb and trunk. Ephraim et al. reported that
      training. Beyond providing activity repetitions, the   approximately 63% and 49% of amputees experienced
      effectiveness of treadmill training may be partially   back pain or pain of their intact limb, respectively
      attributed to the patients’ ability to practice walking   (48). Also, reduced self-selected walking can make
      in a safe environment, especially when utilizing a   participation in functional and recreational activities
                                                    difficult and lead to reduced safety when ambulating
      harness system with or without body-weight support   in the community, such as being able to cross the
      to minimize risk for falls, which improves the patients’   street in an appropriate amount of time (37). This
      confidence when attempting to ambulate at increased   reinforces the importance of reducing spatiotemporal
      speeds.
                                                    gait impairments to improve functional mobility,
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