Page 82 - Teknik Menjawab Soalan PSPM Biologi

Mechanism of Cocaine At Synapse

1. Cocaine blocks the reuptake of dopamine into

presynaptic neuron by binding to transporter protein

2. Dopamine accumulates within the synaptic cleft and

continuously bind to the receptor on the postsynaptic

membrane

3. Continuous depolarisation occurs and impulse is

transmitted repeatedly causes overstimulation of the

postsynaptic membrane

4. To maintain homeostasis, body response by:

➢ reduce synthesis of dopamine

➢ decrease the number of receptors on postsynaptic

membrane

5. By taking in more cocaine, less dopamine is produced

& less number of receptors on postsynaptic membrane
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