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Differences between cAMP and gene

                                                                                 activation




         cAMP activation                                  Gene activation                                  cAMP activation                                  Gene activation

             mechanism                                       mechanism                                          mechanism                                       mechanism


  Involve non-steroid                           Involve steroid hormones                             Transcription and                             Transcription and

  hormones                                                                                           translation do not                            translation do occurs


  Hormones are                                  Hormones are lipid                                   occur

  insoluble in lipid and                        soluble and can enter                                Produce faster                                Produce relatively slower
  cannot enter the cell                         into target cell                                     response                                      response


  Hormones bind to the  Hormones bind to the                                                         Effects of hormones is  Effects of hormones is

  receptor found on cell  receptor in cytoplasm or                                                   short term (ranging                           long term (ranging from a

  membrane                                      nucleus                                              from a few minutes to  few hours to a few days)


  Hormones do not                               Hormones activate a                                  a few hours)

  activate the gene                             specific gene                                        Involve a second                              No second messenger is

                                                                                                     messenger (cAMP) in                           involved because

                                                                                                     the cell                                      hormones can enter



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