Page 9 - Canine Parvovirus Type 2 (CPV-2) and Canine Parvoviral Enteritis

Pathogenesis

• Post-natal infection occur via faecal-oral route

• Virus replicates in lymphoid tissue of the oropharynx, mesenteric lymph nodes, and

thymus

• Virus spread through the blood stream causing viremia

• Predominantly localised along the gastrointestinal tract in epithelial lining

• Attacks the crypt cells in small intestine, causing a lysis and necrosis of enterocytes